Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolites relative to the time needed to isolate cells. T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden
Formato:	Artículo
Lenguaje:	English
Publicado:	eLife Sciences Publications Ltd 2020-07-01
Colección:	eLife
Materias:	pancreatic cancer organoid culture malic enzyme 1 PDAC pyruvate carboxylase metabolic heterogeneity
Acceso en línea:	https://elifesciences.org/articles/56782

Ejemplares similares

PKM2 is not required for pancreatic ductal adenocarcinoma
por: Alissandra L Hillis, et al.
Publicado: (2018-10-01)

The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
por: Edward V. Prochownik, et al.
Publicado: (2021-03-01)

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma
por: Lau, Allison N, et al.
Publicado: (2021)

Pyruvate Carboxylase as a Moonlighting Metabolic Enzyme Protects β‐Cell From Senescence
por: Yumei Yang, et al.
Publicado: (2025-02-01)

Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells
por: Khanti Rattanapornsompong, et al.
Publicado: (2021-03-01)

Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model
por: William Lee, et al.
Publicado: (2013-10-01)

A case of pyruvate carboxylase deficiency with longer survival and normal laboratory findings.
por: shahin koohmanaee, et al.
Publicado: (2021-11-01)

Characterizing Photosynthetic Biofuel Production: Isotopically Non-Stationary 13C Metabolic Flux Analysis on Limonene Producing Synechococcus sp. PCC 7002
por: Darrian M. Newman, et al.
Publicado: (2022-07-01)

Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions
por: Jannick Kappelmann, et al.
Publicado: (2021-01-01)

Insights into the mechanism of abscisic acid-induced 2, 4-D tolerance in maize (Zea mays L.) seedlings: Study on the regulation of osmolytes, fluorescence, photosynthetic carbon reactions, and antioxidant metabolism
por: Bipul Sarkar, et al.
Publicado: (2024-03-01)

Exploration of Patient-Derived Pancreatic Ductal Adenocarcinoma Ex Vivo Tissue for Treatment Response
por: Tímea Szekerczés, et al.
Publicado: (2023-01-01)

Clinical, biochemical, and molecular profiles of three Sri Lankan neonates with pyruvate carboxylase deficiency
por: Jasinge Eresha, et al.
Publicado: (2024-01-01)

ME2 Promotes Hepatocellular Carcinoma Cell Migration through Pyruvate
por: Yanting Yang, et al.
Publicado: (2023-04-01)

Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer
por: Aparna Shinde, et al.
Publicado: (2018-07-01)

Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia
por: Caroline M. Voss, et al.
Publicado: (2021-06-01)

CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor
por: Jarunya Ngamkham, et al.
Publicado: (2022-11-01)

Prenatal onset of the neuroradiologic phenotype of pyruvate carboxylase deficiency due to homozygous PC c.1828G > A mutations
por: Aizeddin A. Mhanni, et al.
Publicado: (2021-09-01)

Manganese orchestrates a metabolic shift leading to the increased bioconversion of glycerol into α-ketoglutarate.
por: Azhar A. Alhasawi, et al.
Publicado: (2016-12-01)

Quality and Composition of Red Wine Fermented with Schizosaccharomyces pombe as Sole Fermentative Yeast, and in Mixed and Sequential Fermentations with Saccharomyces cerevisiae
por: Felipe Palomero, et al.
Publicado: (2014-01-01)

The Fast-Growing Brucella suis Biovar 5 Depends on Phosphoenolpyruvate Carboxykinase and Pyruvate Phosphate Dikinase but Not on Fbp and GlpX Fructose-1,6-Bisphosphatases or Isocitrate Lyase for Full Virulence in Laboratory Models
por: Amaia Zúñiga-Ripa, et al.
Publicado: (2018-04-01)

Silencing of Sb<i>PPCK1-3</i> Negatively Affects Development, Stress Responses and Productivity in Sorghum
por: Jesús Pérez-López, et al.
Publicado: (2023-06-01)

Production of Glyoxylate from Glucose in Engineered <i>Escherichia coli</i>
por: Bui Hoang Dang Long, et al.
Publicado: (2023-05-01)

Expanding the genetic spectrum of the pyruvate carboxylase deficiency with novel missense, deep intronic and structural variants
por: Polina Tsygankova, et al.
Publicado: (2022-09-01)

Metabolome- and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acid production from sugarcane molasses
por: Jun Feng, et al.
Publicado: (2018-04-01)

Corrigendum: Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis
por: Chang Liu, et al.
Publicado: (2021-06-01)

Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis
por: Chang Liu, et al.
Publicado: (2021-05-01)

Metabolic fate of the carboxyl groups of malate and pyruvate and their influence on δ13C of leaf respired CO2 during light enhanced dark respiration
por: Marco M Lehmann, et al.
Publicado: (2016-06-01)

CRISPRi-mediated multigene downregulating redirects the metabolic flux to spinosad biosynthesis in Saccharopolyspora spinosa
por: Zirong Zhu, et al.
Publicado: (2025-06-01)

Case Report: Prenatal neurological injury in a neonate with pyruvate carboxylase deficiency type B
por: Mei Xue
Publicado: (2023-07-01)

Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis
por: Chang Liu, et al.
Publicado: (2021-06-01)

PRDM16 Inhibits Cell Proliferation and Migration via Epithelial-to-Mesenchymal Transition by Directly Targeting Pyruvate Carboxylase in Papillary Thyroid Cancer
por: Wan-Lin Liu, et al.
Publicado: (2021-11-01)

Adult Pancreatoblastoma: Clinical Insights and Outcomes Compared to Pancreatic Ductal Adenocarcinoma (PDAC)
por: Han Yin, et al.
Publicado: (2024-08-01)

piR-hsa-211106 Inhibits the Progression of Lung Adenocarcinoma Through Pyruvate Carboxylase and Enhances Chemotherapy Sensitivity
por: Yongmei Liu, et al.
Publicado: (2021-06-01)

Effects of medium-chain triglycerides on gluconeogenesis and ureagenesis in weaned rats fed a high fat diet
por: Chitose Sugiyama, et al.
Publicado: (2015-12-01)

Metabolism remodeling in pancreatic ductal adenocarcinoma
por: Jin-Tao Li, et al.
Publicado: (2019-11-01)

Metabolic engineering to enhance biosynthesis of both docosahexaenoic acid and odd-chain fatty acids in Schizochytrium sp. S31
por: Fangzhong Wang, et al.
Publicado: (2019-06-01)

Effect of Adenomatous Polyposis Coli Loss on Tumorigenic Potential in Pancreatic Ductal Adenocarcinoma
por: Jennifer M. Cole, et al.
Publicado: (2019-09-01)

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
por: Stefan Christen, et al.
Publicado: (2016-10-01)

Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma
por: Daniela Carbone, et al.
Publicado: (2023-05-01)

Epithelial to Mesenchymal Transition in Patients with Pancreatic Ductal Adenocarcinoma: State-of-the-Art and Therapeutic Opportunities
por: Julie Dardare, et al.
Publicado: (2021-07-01)