Young Age Onset Multivascular Pathology in a Patient with Severe Dyslipidemia: an Incidental Case or a Particular Type of Familial Hypercholesterolemia?
Familial hypercholesterolemia (FH) is a genetic disorder that affects about 1 in 250 people and increases the likelihood of having coronary heart disease at a younger age. We present the case of a 55-year-old patient, known with inferior and anterior myocardial infarction treated by percutaneous cor...
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| Format: | Article |
| Language: | English |
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Sciendo
2022-08-01
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| Series: | Romanian Journal of Cardiology |
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| Online Access: | https://doi.org/10.2478/rjc-2022-0012 |
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| author | Miftode Radu-Stefan Haba Ana-Maria Ursaru Andreea-Maria Petris Antoniu Octavian Mitu Ovidiu |
| author_facet | Miftode Radu-Stefan Haba Ana-Maria Ursaru Andreea-Maria Petris Antoniu Octavian Mitu Ovidiu |
| author_sort | Miftode Radu-Stefan |
| collection | DOAJ |
| description | Familial hypercholesterolemia (FH) is a genetic disorder that affects about 1 in 250 people and increases the likelihood of having coronary heart disease at a younger age. We present the case of a 55-year-old patient, known with inferior and anterior myocardial infarction treated by percutaneous coronary intervention and coronary artery bypass grafts, Leriche syndrome, aortic abdominal aneurysm, and bilateral renal stents—pathologies with onset at a young age—who was admitted for fast-paced palpitations, accompanied by increased fatigue. The coronarography did not reveal any acute lesions, but the presence of ventricular tachycardia at admission required the implantation of a cardiac defibrillator. Since the patient presented with early onset severe systemic atherosclerosis, with a lipid profile dominated by hypo-HDL, doubled by an apolipoprotein A1 deficiency, we considered the diagnosis of familial hypercholesterolemia. Due to the high-risk profile, the association between a statin and a PCSK9 inhibitor was initiated at discharge. At the 1-month follow-up control, a significant reduction of LDL-C has been achieved, with a simultaneous increase of HDL-C serum levels. |
| first_indexed | 2024-04-10T21:29:58Z |
| format | Article |
| id | doaj.art-d786e3647492413291835804edc13425 |
| institution | Directory Open Access Journal |
| issn | 2734-6382 |
| language | English |
| last_indexed | 2024-04-10T21:29:58Z |
| publishDate | 2022-08-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Cardiology |
| spelling | doaj.art-d786e3647492413291835804edc134252023-01-19T13:51:14ZengSciendoRomanian Journal of Cardiology2734-63822022-08-0132316016410.2478/rjc-2022-0012Young Age Onset Multivascular Pathology in a Patient with Severe Dyslipidemia: an Incidental Case or a Particular Type of Familial Hypercholesterolemia?Miftode Radu-Stefan0Haba Ana-Maria1Ursaru Andreea-Maria2Petris Antoniu Octavian3Mitu Ovidiu4Grigore T. Popa University of Medicine and Pharmacy, University Street, nr. 16, Iasi, RomaniaCardiology Clinic, St. Spiridon Clinical Emergency Hospital, Bd. Independentei nr. 1, Iasi, RomaniaCardiology Clinic, St. Spiridon Clinical Emergency Hospital, Bd. Independentei nr. 1, Iasi, RomaniaGrigore T. Popa University of Medicine and Pharmacy, University Street, nr. 16, Iasi, RomaniaGrigore T. Popa University of Medicine and Pharmacy, University Street, nr. 16, Iasi, RomaniaFamilial hypercholesterolemia (FH) is a genetic disorder that affects about 1 in 250 people and increases the likelihood of having coronary heart disease at a younger age. We present the case of a 55-year-old patient, known with inferior and anterior myocardial infarction treated by percutaneous coronary intervention and coronary artery bypass grafts, Leriche syndrome, aortic abdominal aneurysm, and bilateral renal stents—pathologies with onset at a young age—who was admitted for fast-paced palpitations, accompanied by increased fatigue. The coronarography did not reveal any acute lesions, but the presence of ventricular tachycardia at admission required the implantation of a cardiac defibrillator. Since the patient presented with early onset severe systemic atherosclerosis, with a lipid profile dominated by hypo-HDL, doubled by an apolipoprotein A1 deficiency, we considered the diagnosis of familial hypercholesterolemia. Due to the high-risk profile, the association between a statin and a PCSK9 inhibitor was initiated at discharge. At the 1-month follow-up control, a significant reduction of LDL-C has been achieved, with a simultaneous increase of HDL-C serum levels.https://doi.org/10.2478/rjc-2022-0012familial hypercholesterolemiadyslipidemiacoronary syndromepcsk9 inhibitorapolipoprotein a1multivascular diseasehipercolesterolemie familialădislipidemiesindrom coronarianinhibitor pcsk9apolipoproteina a1boală multivasculară |
| spellingShingle | Miftode Radu-Stefan Haba Ana-Maria Ursaru Andreea-Maria Petris Antoniu Octavian Mitu Ovidiu Young Age Onset Multivascular Pathology in a Patient with Severe Dyslipidemia: an Incidental Case or a Particular Type of Familial Hypercholesterolemia? Romanian Journal of Cardiology familial hypercholesterolemia dyslipidemia coronary syndrome pcsk9 inhibitor apolipoprotein a1 multivascular disease hipercolesterolemie familială dislipidemie sindrom coronarian inhibitor pcsk9 apolipoproteina a1 boală multivasculară |
| title | Young Age Onset Multivascular Pathology in a Patient with Severe Dyslipidemia: an Incidental Case or a Particular Type of Familial Hypercholesterolemia? |
| title_full | Young Age Onset Multivascular Pathology in a Patient with Severe Dyslipidemia: an Incidental Case or a Particular Type of Familial Hypercholesterolemia? |
| title_fullStr | Young Age Onset Multivascular Pathology in a Patient with Severe Dyslipidemia: an Incidental Case or a Particular Type of Familial Hypercholesterolemia? |
| title_full_unstemmed | Young Age Onset Multivascular Pathology in a Patient with Severe Dyslipidemia: an Incidental Case or a Particular Type of Familial Hypercholesterolemia? |
| title_short | Young Age Onset Multivascular Pathology in a Patient with Severe Dyslipidemia: an Incidental Case or a Particular Type of Familial Hypercholesterolemia? |
| title_sort | young age onset multivascular pathology in a patient with severe dyslipidemia an incidental case or a particular type of familial hypercholesterolemia |
| topic | familial hypercholesterolemia dyslipidemia coronary syndrome pcsk9 inhibitor apolipoprotein a1 multivascular disease hipercolesterolemie familială dislipidemie sindrom coronarian inhibitor pcsk9 apolipoproteina a1 boală multivasculară |
| url | https://doi.org/10.2478/rjc-2022-0012 |
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