Prevalence, Determinants and Impact of Haemoglobin Phenotype Misdiagnosis Among Parents of Children Living with Sickle Cell Disease in Nigeria
Aim:Nigeria has the highest number of children with sickle cell disease (SCD) with a consistent prevalence of 2 to 3% despite increased awareness and widespread premarital screening. In our practice, we observed that complaints of haemoglobin phenotype misdiagnosis are common among parents of childr...
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| Format: | Article |
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Galenos Yayinevi
2021-09-01
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| Series: | Journal of Pediatric Research |
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http://jpedres.org/archives/archive-detail/article-preview/prevalence-determinants-and-mpact-of-haemoglobin-p/48637
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| author | Motunrayo Oluwabukola Adekunle Oyesola Ojewunmi Adeola Barakat Animasahun Faith Ozavisa Lawani Peter Odion Ubuane |
| author_facet | Motunrayo Oluwabukola Adekunle Oyesola Ojewunmi Adeola Barakat Animasahun Faith Ozavisa Lawani Peter Odion Ubuane |
| author_sort | Motunrayo Oluwabukola Adekunle |
| collection | DOAJ |
| description | Aim:Nigeria has the highest number of children with sickle cell disease (SCD) with a consistent prevalence of 2 to 3% despite increased awareness and widespread premarital screening. In our practice, we observed that complaints of haemoglobin phenotype misdiagnosis are common among parents of children living with SCD. The present study was thus carried out to identify the prevalence, determinants, as well as the perceived impacts of haemoglobin phenotype misdiagnosis in Lagos, Nigeria. Materials and Methods:This study included the parents of children with SCD aged below 18 years. Interviewer administered questionnaires were used to obtain relevant biodata, sociodemographic data and an assessment of the perceived impact from both caregivers and their children, between May and July 2019.Results:Fifty-nine (32.4%) out of the 182 parents recruited had a previous haemoglobin phenotype misdiagnosis. Misdiagnosis was significantly more in individuals in the upper social class and those that had their tests performed in private laboratories. Clinical, psychosocial and economic impacts of having an affected child with SCD were reported.Conclusion:The frequency of wrong haemoglobin phenotype diagnosis is alarmingly rampant amongst the parents of children with SCD. This is potentially devastating to these families and to society; hence, the government needs to act by auditing and enforcing regulatory oversight of laboratories as well as instituting a nationwide new-born screening programme to replace the existing widespread use of haemoglobin electrophoresis for the diagnosis of SCD. |
| first_indexed | 2024-04-10T13:18:21Z |
| format | Article |
| id | doaj.art-d7879cf6b2a845cc87596333330de9bf |
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| issn | 2147-9445 2587-2478 |
| language | English |
| last_indexed | 2024-04-10T13:18:21Z |
| publishDate | 2021-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-d7879cf6b2a845cc87596333330de9bf2023-02-15T16:12:11ZengGalenos YayineviJournal of Pediatric Research2147-94452587-24782021-09-018323924510.4274/jpr.galenos.2020.5436613049054Prevalence, Determinants and Impact of Haemoglobin Phenotype Misdiagnosis Among Parents of Children Living with Sickle Cell Disease in NigeriaMotunrayo Oluwabukola Adekunle0Oyesola Ojewunmi1Adeola Barakat Animasahun2Faith Ozavisa Lawani3Peter Odion Ubuane4 Lagos State University Teaching Hospital, Department of Paediatrics, Lagos, Nigeria DNA Laboratory, Sickle Cell Foundation Nigeria, Lagos, Nigeria Lagos State University College of Medicine, Department of Paediatrics and Child Health, Lagos, Nigeria Lagos State University Teaching Hospital, Department of Paediatrics, Lagos, Nigeria Lagos State University Teaching Hospital, Department of Paediatrics, Lagos, Nigeria Aim:Nigeria has the highest number of children with sickle cell disease (SCD) with a consistent prevalence of 2 to 3% despite increased awareness and widespread premarital screening. In our practice, we observed that complaints of haemoglobin phenotype misdiagnosis are common among parents of children living with SCD. The present study was thus carried out to identify the prevalence, determinants, as well as the perceived impacts of haemoglobin phenotype misdiagnosis in Lagos, Nigeria. Materials and Methods:This study included the parents of children with SCD aged below 18 years. Interviewer administered questionnaires were used to obtain relevant biodata, sociodemographic data and an assessment of the perceived impact from both caregivers and their children, between May and July 2019.Results:Fifty-nine (32.4%) out of the 182 parents recruited had a previous haemoglobin phenotype misdiagnosis. Misdiagnosis was significantly more in individuals in the upper social class and those that had their tests performed in private laboratories. Clinical, psychosocial and economic impacts of having an affected child with SCD were reported.Conclusion:The frequency of wrong haemoglobin phenotype diagnosis is alarmingly rampant amongst the parents of children with SCD. This is potentially devastating to these families and to society; hence, the government needs to act by auditing and enforcing regulatory oversight of laboratories as well as instituting a nationwide new-born screening programme to replace the existing widespread use of haemoglobin electrophoresis for the diagnosis of SCD. http://jpedres.org/archives/archive-detail/article-preview/prevalence-determinants-and-mpact-of-haemoglobin-p/48637 misdiagnosishaemoglobin-phenotypesickle cell diseaselaboratorynigeria |
| spellingShingle | Motunrayo Oluwabukola Adekunle Oyesola Ojewunmi Adeola Barakat Animasahun Faith Ozavisa Lawani Peter Odion Ubuane Prevalence, Determinants and Impact of Haemoglobin Phenotype Misdiagnosis Among Parents of Children Living with Sickle Cell Disease in Nigeria Journal of Pediatric Research misdiagnosis haemoglobin-phenotype sickle cell disease laboratory nigeria |
| title | Prevalence, Determinants and Impact of Haemoglobin Phenotype Misdiagnosis Among Parents of Children Living with Sickle Cell Disease in Nigeria |
| title_full | Prevalence, Determinants and Impact of Haemoglobin Phenotype Misdiagnosis Among Parents of Children Living with Sickle Cell Disease in Nigeria |
| title_fullStr | Prevalence, Determinants and Impact of Haemoglobin Phenotype Misdiagnosis Among Parents of Children Living with Sickle Cell Disease in Nigeria |
| title_full_unstemmed | Prevalence, Determinants and Impact of Haemoglobin Phenotype Misdiagnosis Among Parents of Children Living with Sickle Cell Disease in Nigeria |
| title_short | Prevalence, Determinants and Impact of Haemoglobin Phenotype Misdiagnosis Among Parents of Children Living with Sickle Cell Disease in Nigeria |
| title_sort | prevalence determinants and impact of haemoglobin phenotype misdiagnosis among parents of children living with sickle cell disease in nigeria |
| topic | misdiagnosis haemoglobin-phenotype sickle cell disease laboratory nigeria |
| url |
http://jpedres.org/archives/archive-detail/article-preview/prevalence-determinants-and-mpact-of-haemoglobin-p/48637
|
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