Design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to wounds
Despite advancements in wound management, chronic wounds still fail to heal in an appropriate time and manner. Hydrophobic drugs of interest to the pharmaceutical industry exist that are suggested to reduce inflammation and aid in the wound healing process; however, delivering these drugs poses a ch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2022-11-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/1151/ |
| _version_ | 1797825345220509696 |
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| author | Bradley Cory Joshua S Boateng |
| author_facet | Bradley Cory Joshua S Boateng |
| author_sort | Bradley Cory |
| collection | DOAJ |
| description | Despite advancements in wound management, chronic wounds still fail to heal in an appropriate time and manner. Hydrophobic drugs of interest to the pharmaceutical industry exist that are suggested to reduce inflammation and aid in the wound healing process; however, delivering these drugs poses a challenge both in terms of ease of formulation processing and drug release characteristics when applied in vivo. Naturally occurring, biocompatible, and bioactive excipients, such as hydroxyethylcellulose (HEC) and citric acid (CA) are hydrophilic and widely used in wound management and delivery of soluble drugs. However, hydrophobic drugs are not compatible in this environment without the addition of molecules, such as β-cyclodextrin(βCD), which acts as a drug carrier and allows drug delivery. This study investigated the use of CA in formulation development to achieve crosslinking of HEC and βCD to allow the incorporation of poorly soluble model drugs. The prepared films have been characterized for their functional physico-chemical properties relevant for wound healing applications. |
| first_indexed | 2024-03-13T10:52:44Z |
| format | Article |
| id | doaj.art-d7886311695d47a2a6a4791acfc70772 |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-13T10:52:44Z |
| publishDate | 2022-11-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-d7886311695d47a2a6a4791acfc707722023-05-17T10:57:06ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562022-11-017210.5920/bjpharm.1151Design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to woundsBradley Cory0Joshua S BoatengUniversity of GreenwichDespite advancements in wound management, chronic wounds still fail to heal in an appropriate time and manner. Hydrophobic drugs of interest to the pharmaceutical industry exist that are suggested to reduce inflammation and aid in the wound healing process; however, delivering these drugs poses a challenge both in terms of ease of formulation processing and drug release characteristics when applied in vivo. Naturally occurring, biocompatible, and bioactive excipients, such as hydroxyethylcellulose (HEC) and citric acid (CA) are hydrophilic and widely used in wound management and delivery of soluble drugs. However, hydrophobic drugs are not compatible in this environment without the addition of molecules, such as β-cyclodextrin(βCD), which acts as a drug carrier and allows drug delivery. This study investigated the use of CA in formulation development to achieve crosslinking of HEC and βCD to allow the incorporation of poorly soluble model drugs. The prepared films have been characterized for their functional physico-chemical properties relevant for wound healing applications.https://www.bjpharm.org.uk/article/id/1151/beta cyclodextrincitric acidhydrophobic drughydroxyethlcellulose |
| spellingShingle | Bradley Cory Joshua S Boateng Design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to wounds British Journal of Pharmacy beta cyclodextrin citric acid hydrophobic drug hydroxyethlcellulose |
| title | Design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to wounds |
| title_full | Design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to wounds |
| title_fullStr | Design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to wounds |
| title_full_unstemmed | Design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to wounds |
| title_short | Design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to wounds |
| title_sort | design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to wounds |
| topic | beta cyclodextrin citric acid hydrophobic drug hydroxyethlcellulose |
| url | https://www.bjpharm.org.uk/article/id/1151/ |
| work_keys_str_mv | AT bradleycory designoptimisationandcharacterisationoffilmsfordeliveringpoorlysolublehydrophobicdrugstowounds AT joshuasboateng designoptimisationandcharacterisationoffilmsfordeliveringpoorlysolublehydrophobicdrugstowounds |