Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients

Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients

Abstract Background Immune checkpoint inhibitors (ICIs) are a therapeutic strategy for various cancers although only a subset of patients respond to the therapy. Identifying patients more prone to respond to ICIs may increase the therapeutic benefit and allow studying new approaches for resistant pa...

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Bibliographic Details
Main Authors: Andrea Sacconi, Paola Muti, Claudio Pulito, Giulia Urbani, Matteo Allegretti, Raul Pellini, Nikolay Mehterov, Uri Ben-David, Sabrina Strano, Paolo Bossi, Giovanni Blandino
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Molecular Cancer
Subjects:
HNSCC
Immunotherapy
Immune checkpoint inhibitor
p53
PDL1
c-MYC
Online Access:https://doi.org/10.1186/s12943-023-01905-9

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