Synthesis and Biological Properties of 5-(1H-1,2,3-Triazol-4-yl)isoxazolidines: A New Class of C-Nucleosides

Synthesis and Biological Properties of 5-(1H-1,2,3-Triazol-4-yl)isoxazolidines: A New Class of C-Nucleosides

A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was observed for compounds 17a and 17b: the growth inhibitory effect reaches the 50% in HepG2 a...

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Bibliographic Details
Main Authors:	Salvatore V. Giofrè, Roberto Romeo, Caterina Carnovale, Raffaella Mancuso, Santa Cirmi, Michele Navarra, Adriana Garozzo, Maria A. Chiacchio
Format:	Article
Language:	English
Published:	MDPI AG 2015-03-01
Series:	Molecules
Subjects:	vinyl triazoles C-Nucleosides 1,3-dipolar cycloaddition antiproliferative activity microwave
Online Access:	http://www.mdpi.com/1420-3049/20/4/5260

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