Generalized Analytical Model for Enzymatic BioFET Transistors
Software tools that are able to simulate the functionality or interactions of an enzyme biosensor with Metal Oxide Semiconductor (MOS), or any Field Effect Transistor (FET) as transducer, represent a gap in the market. Bio-devices, or Enzyme-FET, cannot be simulated by Atlas or equivalent software....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/12/7/474 |
| _version_ | 1797407271364329472 |
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| author | Cristian Ravariu Avireni Srinivasulu Dan Eduard Mihaiescu Sarada Musala |
| author_facet | Cristian Ravariu Avireni Srinivasulu Dan Eduard Mihaiescu Sarada Musala |
| author_sort | Cristian Ravariu |
| collection | DOAJ |
| description | Software tools that are able to simulate the functionality or interactions of an enzyme biosensor with Metal Oxide Semiconductor (MOS), or any Field Effect Transistor (FET) as transducer, represent a gap in the market. Bio-devices, or Enzyme-FET, cannot be simulated by Atlas or equivalent software. This paper resolves this issue for the enzymatic block coupled with FETs’ role within biosensors. The first block has the concentration of biological analyte as the input signal and concentration of ions from the enzymatic reaction as the output signal. The modeling begins from the Michaelis–Menten formalism and analyzes the time dependence of the product concentrations that become the input signal for the next FET block. Comparisons within experimental data are provided. The analytical model proposed in this paper represents a general analytical tool in the design stage for enzymatic transistors used in clinical practices. |
| first_indexed | 2024-03-09T03:38:50Z |
| format | Article |
| id | doaj.art-d78b8f3504d2413fa4c4ec7404409f11 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T03:38:50Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-d78b8f3504d2413fa4c4ec7404409f112023-12-03T14:44:06ZengMDPI AGBiosensors2079-63742022-06-0112747410.3390/bios12070474Generalized Analytical Model for Enzymatic BioFET TransistorsCristian Ravariu0Avireni Srinivasulu1Dan Eduard Mihaiescu2Sarada Musala3BioNEC Group, Department of Electronic Devices Circuits and Architectures, Faculty of Electronics ETTI, Polytechnic University of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaSchool of Engineering & Technology, K.R. Mangalam University, Gurugram 122103, Haryana, IndiaOrganic Chemistry Department, Faculty of Chemistry, Polytechnic University of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaDepartment of Electronics and Communication Engineering, Vignan’s Foundation for Science, Technology and Research, Guntur 522213, Andhra Pradesh, IndiaSoftware tools that are able to simulate the functionality or interactions of an enzyme biosensor with Metal Oxide Semiconductor (MOS), or any Field Effect Transistor (FET) as transducer, represent a gap in the market. Bio-devices, or Enzyme-FET, cannot be simulated by Atlas or equivalent software. This paper resolves this issue for the enzymatic block coupled with FETs’ role within biosensors. The first block has the concentration of biological analyte as the input signal and concentration of ions from the enzymatic reaction as the output signal. The modeling begins from the Michaelis–Menten formalism and analyzes the time dependence of the product concentrations that become the input signal for the next FET block. Comparisons within experimental data are provided. The analytical model proposed in this paper represents a general analytical tool in the design stage for enzymatic transistors used in clinical practices.https://www.mdpi.com/2079-6374/12/7/474ENFET modelingenzyme kineticsbio-nano-electronics |
| spellingShingle | Cristian Ravariu Avireni Srinivasulu Dan Eduard Mihaiescu Sarada Musala Generalized Analytical Model for Enzymatic BioFET Transistors Biosensors ENFET modeling enzyme kinetics bio-nano-electronics |
| title | Generalized Analytical Model for Enzymatic BioFET Transistors |
| title_full | Generalized Analytical Model for Enzymatic BioFET Transistors |
| title_fullStr | Generalized Analytical Model for Enzymatic BioFET Transistors |
| title_full_unstemmed | Generalized Analytical Model for Enzymatic BioFET Transistors |
| title_short | Generalized Analytical Model for Enzymatic BioFET Transistors |
| title_sort | generalized analytical model for enzymatic biofet transistors |
| topic | ENFET modeling enzyme kinetics bio-nano-electronics |
| url | https://www.mdpi.com/2079-6374/12/7/474 |
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