Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated Patient
Lung cancer is a large heterogeneous family of malignancies, with tumors containing more than one subtype are very common. Over 50 different histological variants are recognized within the WHO typing system. Small Cell Lung Cancer comprises approximately 20% of all lung cancers and exhibits a neuro...
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| Format: | Article |
| Language: | English |
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Universitas Sultan Agung Semarang
2017-03-01
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| Series: | Sains Medika |
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| Online Access: | http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1178 |
| _version_ | 1811193125506383872 |
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| author | Susilorini Susilorini Dik Puspasari Siti Amarwati Bambang Endro |
| author_facet | Susilorini Susilorini Dik Puspasari Siti Amarwati Bambang Endro |
| author_sort | Susilorini Susilorini |
| collection | DOAJ |
| description | Lung cancer is a large heterogeneous family of malignancies, with tumors containing more than one subtype are very common. Over 50 different histological variants are recognized within the WHO typing system. Small Cell Lung Cancer comprises approximately 20% of all lung cancers and exhibits a neuroendocrine phenotype while Non Small Cell Lung Carsinoma (NSCLC) lacks these features and makes up the remaining 80% of cases. This case was reported in view of the rarity of this combination of morphologic patterns. The incidence of c- SCLC (Combined- Small Cell Lung Carsinoma) has been reported ranging from less than 1% to 14.6% of all SCLC. Mixed lung cancer in untreated patients suggests a common endodermal origin for c-SCLC which contains small-cell and non-small-cell pulmonary tumors. Quoix et al found that presentation as a solitary pulmonary nodule (SPN) is particularly indicative of a c-SCLC. Combined- Small Cell Lung Carsinoma contains a squamous cell and/or adenocarcinoma component. It’s becoming more important for pathologists to correctly subclassify NSCLC’s as distinct tumor entities, or as components of c-SCLC cause it’s more agrresive. A 46-year-old smoker man was referred because of rapid growth of a solitary nodule mass revealed by chest radiography with brain and limfonodes metastases. There was mixed histological feature including adenocarsinoma, squamous cell carsinoma and large cell carsinoma. The patient is dead after a few weeks later. It was revealed a panel immunohistochemistry stain (CK-7, CK-20, TTF-1, P63 and Chromoganin). It was concluded as c- SCLC. |
| first_indexed | 2024-04-12T00:03:17Z |
| format | Article |
| id | doaj.art-d78f102df9b74210b52117fb81ce6f5c |
| institution | Directory Open Access Journal |
| issn | 2085-1545 2339-093X |
| language | English |
| last_indexed | 2024-04-12T00:03:17Z |
| publishDate | 2017-03-01 |
| publisher | Universitas Sultan Agung Semarang |
| record_format | Article |
| series | Sains Medika |
| spelling | doaj.art-d78f102df9b74210b52117fb81ce6f5c2022-12-22T03:56:10ZengUniversitas Sultan Agung SemarangSains Medika2085-15452339-093X2017-03-0172768010.26532/sainsmed.v7i2.11781044Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated PatientSusilorini Susilorini0Dik Puspasari1Siti Amarwati2Bambang Endro3Department of Pathology Anatomy, Faculty of Medicine, Sultan Agung Islamic University Semarang Corresponden Author, email : susilorinidr@gmail.comDepartment of Pathology Anatomy, Faculty of Medicine, Diponegoro University, SemarangDepartment of Pathology Anatomy, Faculty of Medicine, Diponegoro University, SemarangDepartment of Pathology Anatomy, Faculty of Medicine, Diponegoro University, SemarangLung cancer is a large heterogeneous family of malignancies, with tumors containing more than one subtype are very common. Over 50 different histological variants are recognized within the WHO typing system. Small Cell Lung Cancer comprises approximately 20% of all lung cancers and exhibits a neuroendocrine phenotype while Non Small Cell Lung Carsinoma (NSCLC) lacks these features and makes up the remaining 80% of cases. This case was reported in view of the rarity of this combination of morphologic patterns. The incidence of c- SCLC (Combined- Small Cell Lung Carsinoma) has been reported ranging from less than 1% to 14.6% of all SCLC. Mixed lung cancer in untreated patients suggests a common endodermal origin for c-SCLC which contains small-cell and non-small-cell pulmonary tumors. Quoix et al found that presentation as a solitary pulmonary nodule (SPN) is particularly indicative of a c-SCLC. Combined- Small Cell Lung Carsinoma contains a squamous cell and/or adenocarcinoma component. It’s becoming more important for pathologists to correctly subclassify NSCLC’s as distinct tumor entities, or as components of c-SCLC cause it’s more agrresive. A 46-year-old smoker man was referred because of rapid growth of a solitary nodule mass revealed by chest radiography with brain and limfonodes metastases. There was mixed histological feature including adenocarsinoma, squamous cell carsinoma and large cell carsinoma. The patient is dead after a few weeks later. It was revealed a panel immunohistochemistry stain (CK-7, CK-20, TTF-1, P63 and Chromoganin). It was concluded as c- SCLC.http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1178Mixed lung cancercombined Small Cell Lung Carsinoma (c-SCLC)solitary nodul |
| spellingShingle | Susilorini Susilorini Dik Puspasari Siti Amarwati Bambang Endro Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated Patient Sains Medika Mixed lung cancer combined Small Cell Lung Carsinoma (c-SCLC) solitary nodul |
| title | Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated Patient |
| title_full | Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated Patient |
| title_fullStr | Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated Patient |
| title_full_unstemmed | Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated Patient |
| title_short | Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated Patient |
| title_sort | mixed lung cancer in 46 years old male smoker untreated patient |
| topic | Mixed lung cancer combined Small Cell Lung Carsinoma (c-SCLC) solitary nodul |
| url | http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1178 |
| work_keys_str_mv | AT susilorinisusilorini mixedlungcancerin46yearsoldmalesmokeruntreatedpatient AT dikpuspasari mixedlungcancerin46yearsoldmalesmokeruntreatedpatient AT sitiamarwati mixedlungcancerin46yearsoldmalesmokeruntreatedpatient AT bambangendro mixedlungcancerin46yearsoldmalesmokeruntreatedpatient |