GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids
This mini review investigates the importance of GABAergic interneurons for the network function of human-induced pluripotent stem cells (hiPSC)-derived brain organoids. The presented evidence suggests that the abundance, diversity and three-dimensional cortical organization of GABAergic interneurons...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-04-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1389335/full |
| _version_ | 1797214316598919168 |
|---|---|
| author | Sebastian H. Heesen Georg Köhr Georg Köhr |
| author_facet | Sebastian H. Heesen Georg Köhr Georg Köhr |
| author_sort | Sebastian H. Heesen |
| collection | DOAJ |
| description | This mini review investigates the importance of GABAergic interneurons for the network function of human-induced pluripotent stem cells (hiPSC)-derived brain organoids. The presented evidence suggests that the abundance, diversity and three-dimensional cortical organization of GABAergic interneurons are the primary elements responsible for the creation of synchronous neuronal firing patterns. Without intricate inhibition, coupled oscillatory patterns cannot reach a sufficient complexity to transfer spatiotemporal information constituting physiological network function. Furthermore, human-specific brain network function seems to be mediated by a more complex and interconnected inhibitory structure that remains developmentally flexible for a longer period when compared to rodents. This suggests that several characteristics of human brain networks cannot be captured by rodent models, emphasizing the need for model systems like organoids that adequately mimic physiological human brain function in vitro. |
| first_indexed | 2024-04-24T11:12:14Z |
| format | Article |
| id | doaj.art-d79073f5017f49d28c24bc5dd4d18045 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-24T11:12:14Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-d79073f5017f49d28c24bc5dd4d180452024-04-11T12:52:11ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-04-011810.3389/fncel.2024.13893351389335GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoidsSebastian H. Heesen0Georg Köhr1Georg Köhr2Molecular and Behavioural Neurobiology, Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, GermanyDepartment of Neurophysiology, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, GermanyPhysiology of Neural Networks, Central Institute of Mental Health, Heidelberg University, Mannheim, GermanyThis mini review investigates the importance of GABAergic interneurons for the network function of human-induced pluripotent stem cells (hiPSC)-derived brain organoids. The presented evidence suggests that the abundance, diversity and three-dimensional cortical organization of GABAergic interneurons are the primary elements responsible for the creation of synchronous neuronal firing patterns. Without intricate inhibition, coupled oscillatory patterns cannot reach a sufficient complexity to transfer spatiotemporal information constituting physiological network function. Furthermore, human-specific brain network function seems to be mediated by a more complex and interconnected inhibitory structure that remains developmentally flexible for a longer period when compared to rodents. This suggests that several characteristics of human brain networks cannot be captured by rodent models, emphasizing the need for model systems like organoids that adequately mimic physiological human brain function in vitro.https://www.frontiersin.org/articles/10.3389/fncel.2024.1389335/fullhuman-specific inhibitionGABAergic interneuronsE-I balancephase-amplitude-couplingfunctional neural networks2D/3D neuronal cell culture |
| spellingShingle | Sebastian H. Heesen Georg Köhr Georg Köhr GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids Frontiers in Cellular Neuroscience human-specific inhibition GABAergic interneurons E-I balance phase-amplitude-coupling functional neural networks 2D/3D neuronal cell culture |
| title | GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids |
| title_full | GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids |
| title_fullStr | GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids |
| title_full_unstemmed | GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids |
| title_short | GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids |
| title_sort | gabaergic interneuron diversity and organization are crucial for the generation of human specific functional neural networks in cerebral organoids |
| topic | human-specific inhibition GABAergic interneurons E-I balance phase-amplitude-coupling functional neural networks 2D/3D neuronal cell culture |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1389335/full |
| work_keys_str_mv | AT sebastianhheesen gabaergicinterneurondiversityandorganizationarecrucialforthegenerationofhumanspecificfunctionalneuralnetworksincerebralorganoids AT georgkohr gabaergicinterneurondiversityandorganizationarecrucialforthegenerationofhumanspecificfunctionalneuralnetworksincerebralorganoids AT georgkohr gabaergicinterneurondiversityandorganizationarecrucialforthegenerationofhumanspecificfunctionalneuralnetworksincerebralorganoids |