Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines

Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines

<p>Abstract</p> <p>Background</p> <p>The phosphatidylinositol-3-kinase (PI3K-PKB), mitogen activated protein kinase (MEK-ERK) and the mammalian target of rapamycin (mTOR- p70S6K), are thought to regulate many aspects of tumour cell proliferation and survival. We have ex...

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Bibliographic Details
Main Authors: Kim Ji Eun, Stones Clare, Joseph Wayne R, Leung Euphemia, Finlay Graeme J, Shelling Andrew N, Phillips Wayne A, Shepherd Peter R, Baguley Bruce C
Format: Article
Language:English
Published: BMC 2012-04-01
Series:BMC Cancer
Subjects:
Phosphatidylinositol-3-kinase
ERK
mTOR
Phosphorylation
Melanoma and Melanocyte
Online Access:http://www.biomedcentral.com/1471-2407/12/141

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