Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch
Abstract Itch is a distinctive sensation that causes a specific affection and scratching reaction. The anterior cingulate cortex (ACC) has been linked to itch sensation in numerous studies; however, its precise function in processing pruritic inputs remains unknown. Distinguishing the precise role o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13041-023-01037-7 |
| _version_ | 1827922728495087616 |
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| author | Chiwoo Lee Jihae Oh Jae-Hyung Lee Bong-Kiun Kaang Hyoung-Gon Ko |
| author_facet | Chiwoo Lee Jihae Oh Jae-Hyung Lee Bong-Kiun Kaang Hyoung-Gon Ko |
| author_sort | Chiwoo Lee |
| collection | DOAJ |
| description | Abstract Itch is a distinctive sensation that causes a specific affection and scratching reaction. The anterior cingulate cortex (ACC) has been linked to itch sensation in numerous studies; however, its precise function in processing pruritic inputs remains unknown. Distinguishing the precise role of the ACC in itch sensation can be challenging because of its capacity to conduct heterologous neurophysiological activities. Here, we used in vivo calcium imaging to examine how ACC neurons in free-moving mice react to pruritogenic histamine. In particular, we focused on how the activity of the ACC neurons varied before and after the scratching response. We discovered that although the change in neuronal activity was not synchronized with the scratching reaction, the overall activity of itch-responsive neurons promptly decreased after the scratching response. These findings suggest that the ACC does not directly elicit the feeling of itchiness. |
| first_indexed | 2024-03-13T04:46:53Z |
| format | Article |
| id | doaj.art-d791ac6f0e194ba9a98bd4d9bfa76ff5 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-03-13T04:46:53Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-d791ac6f0e194ba9a98bd4d9bfa76ff52023-06-18T11:28:24ZengBMCMolecular Brain1756-66062023-06-011611410.1186/s13041-023-01037-7Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itchChiwoo Lee0Jihae Oh1Jae-Hyung Lee2Bong-Kiun Kaang3Hyoung-Gon Ko4Department of Biological Sciences, College of Natural Sciences, Seoul National UniversityDepartment of Biological Sciences, College of Natural Sciences, Seoul National UniversityDepartment of Oral Microbiology, College of Dentistry, Kyung Hee UniversityDepartment of Biological Sciences, College of Natural Sciences, Seoul National UniversityDepartment of Anatomy and Neurobiology, School of Dentistry, Kyungpook National UniversityAbstract Itch is a distinctive sensation that causes a specific affection and scratching reaction. The anterior cingulate cortex (ACC) has been linked to itch sensation in numerous studies; however, its precise function in processing pruritic inputs remains unknown. Distinguishing the precise role of the ACC in itch sensation can be challenging because of its capacity to conduct heterologous neurophysiological activities. Here, we used in vivo calcium imaging to examine how ACC neurons in free-moving mice react to pruritogenic histamine. In particular, we focused on how the activity of the ACC neurons varied before and after the scratching response. We discovered that although the change in neuronal activity was not synchronized with the scratching reaction, the overall activity of itch-responsive neurons promptly decreased after the scratching response. These findings suggest that the ACC does not directly elicit the feeling of itchiness.https://doi.org/10.1186/s13041-023-01037-7Anterior cingulate cortexItchIn vivo calcium imaging |
| spellingShingle | Chiwoo Lee Jihae Oh Jae-Hyung Lee Bong-Kiun Kaang Hyoung-Gon Ko Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch Molecular Brain Anterior cingulate cortex Itch In vivo calcium imaging |
| title | Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch |
| title_full | Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch |
| title_fullStr | Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch |
| title_full_unstemmed | Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch |
| title_short | Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch |
| title_sort | loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine induced itch |
| topic | Anterior cingulate cortex Itch In vivo calcium imaging |
| url | https://doi.org/10.1186/s13041-023-01037-7 |
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