Hydrogel-Based Microneedle as a Drug Delivery System
The skin is considered the largest and most accessible organ in the human body, and allows the use of noninvasive and efficient strategies for drug administration, such as the transdermal drug delivery system (TDDS). TDDSs are systems or patches, with the ability and purpose to deliver effective and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/10/2444 |
| _version_ | 1827720121541459968 |
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| author | David Filho Marcelo Guerrero Manuel Pariguana Adolfo Marican Esteban F. Durán-Lara |
| author_facet | David Filho Marcelo Guerrero Manuel Pariguana Adolfo Marican Esteban F. Durán-Lara |
| author_sort | David Filho |
| collection | DOAJ |
| description | The skin is considered the largest and most accessible organ in the human body, and allows the use of noninvasive and efficient strategies for drug administration, such as the transdermal drug delivery system (TDDS). TDDSs are systems or patches, with the ability and purpose to deliver effective and therapeutic doses of drugs through the skin. Regarding the specific interaction between hydrogels (HG) and microneedles (MNs), we seek to find out how this combination would be applied in the context of drug delivery, and we detail some possible advantages of the methods used. Depending on the components belonging to the HG matrix, we can obtain some essential characteristics that make the combination of hydrogels–microneedles (HG–MNs) very advantageous, such as the response to external stimuli, among others. Based on multiple characteristics provided by HGMNs that are depicted in this work, it is possible to obtain unique properties that include controlled, sustained, and localized drug release, as well as the possibility of a synergistic association between the components of the formulation and the combination of more than one bioactive component. In conclusion, a system based on HG–MNs can offer many advantages in the biomedical field, bringing to light a new technological and safe system for improving the pharmacokinetics and pharmacodynamics of drugs and new treatment perspectives. |
| first_indexed | 2024-03-10T20:59:05Z |
| format | Article |
| id | doaj.art-d792b85e81a84ca39acacb849908bb1c |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T20:59:05Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d792b85e81a84ca39acacb849908bb1c2023-11-19T17:44:36ZengMDPI AGPharmaceutics1999-49232023-10-011510244410.3390/pharmaceutics15102444Hydrogel-Based Microneedle as a Drug Delivery SystemDavid Filho0Marcelo Guerrero1Manuel Pariguana2Adolfo Marican3Esteban F. Durán-Lara4Laboratory of Bio & Nano Materials, Drug Delivery and Controlled Release, Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca 3460000, ChileLaboratory of Bio & Nano Materials, Drug Delivery and Controlled Release, Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca 3460000, ChileLaboratory of Bio & Nano Materials, Drug Delivery and Controlled Release, Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca 3460000, ChileLaboratory of Bio & Nano Materials, Drug Delivery and Controlled Release, Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca 3460000, ChileLaboratory of Bio & Nano Materials, Drug Delivery and Controlled Release, Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca 3460000, ChileThe skin is considered the largest and most accessible organ in the human body, and allows the use of noninvasive and efficient strategies for drug administration, such as the transdermal drug delivery system (TDDS). TDDSs are systems or patches, with the ability and purpose to deliver effective and therapeutic doses of drugs through the skin. Regarding the specific interaction between hydrogels (HG) and microneedles (MNs), we seek to find out how this combination would be applied in the context of drug delivery, and we detail some possible advantages of the methods used. Depending on the components belonging to the HG matrix, we can obtain some essential characteristics that make the combination of hydrogels–microneedles (HG–MNs) very advantageous, such as the response to external stimuli, among others. Based on multiple characteristics provided by HGMNs that are depicted in this work, it is possible to obtain unique properties that include controlled, sustained, and localized drug release, as well as the possibility of a synergistic association between the components of the formulation and the combination of more than one bioactive component. In conclusion, a system based on HG–MNs can offer many advantages in the biomedical field, bringing to light a new technological and safe system for improving the pharmacokinetics and pharmacodynamics of drugs and new treatment perspectives.https://www.mdpi.com/1999-4923/15/10/2444biomedical applicationsdelivery systemshydrogelsmicroneedles |
| spellingShingle | David Filho Marcelo Guerrero Manuel Pariguana Adolfo Marican Esteban F. Durán-Lara Hydrogel-Based Microneedle as a Drug Delivery System Pharmaceutics biomedical applications delivery systems hydrogels microneedles |
| title | Hydrogel-Based Microneedle as a Drug Delivery System |
| title_full | Hydrogel-Based Microneedle as a Drug Delivery System |
| title_fullStr | Hydrogel-Based Microneedle as a Drug Delivery System |
| title_full_unstemmed | Hydrogel-Based Microneedle as a Drug Delivery System |
| title_short | Hydrogel-Based Microneedle as a Drug Delivery System |
| title_sort | hydrogel based microneedle as a drug delivery system |
| topic | biomedical applications delivery systems hydrogels microneedles |
| url | https://www.mdpi.com/1999-4923/15/10/2444 |
| work_keys_str_mv | AT davidfilho hydrogelbasedmicroneedleasadrugdeliverysystem AT marceloguerrero hydrogelbasedmicroneedleasadrugdeliverysystem AT manuelpariguana hydrogelbasedmicroneedleasadrugdeliverysystem AT adolfomarican hydrogelbasedmicroneedleasadrugdeliverysystem AT estebanfduranlara hydrogelbasedmicroneedleasadrugdeliverysystem |