Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligand
New ruthenium(III) complexes with 3-(Benzothiazol-2-yliminomethyl)-phenol (HL) ligand have been synthesized and characterized with the aid of elemental analysis, IR, electronic, and electron paramagnetic resonance spectroscopic techniques. The binding mode of the ligand and complexes with DNA and th...
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| Format: | Article |
| Language: | English |
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Growing Science
2019-06-01
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| Series: | Current Chemistry Letters |
| Subjects: | |
| Online Access: | http://www.growingscience.com/ccl/Vol8/ccl_2019_13.pdf |
| _version_ | 1818055463615332352 |
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| author | Sathiyaraj Subbaiyan Indhumathi Ponnusamy |
| author_facet | Sathiyaraj Subbaiyan Indhumathi Ponnusamy |
| author_sort | Sathiyaraj Subbaiyan |
| collection | DOAJ |
| description | New ruthenium(III) complexes with 3-(Benzothiazol-2-yliminomethyl)-phenol (HL) ligand have been synthesized and characterized with the aid of elemental analysis, IR, electronic, and electron paramagnetic resonance spectroscopic techniques. The binding mode of the ligand and complexes with DNA and their ability to bind DNA have been investigated by UV-vis absorption titration. In addition, the ligand and complexes have been subjected to antioxidant activity tests which showed that HL and its ruthenium(III) complexes possess significant scavenging effect against DPPH and OH radicals. Cytotoxic activities of the ligand and ruthenium(III) complexes showed that the ruthenium(III) complexes exhibited more effective cytotoxic activity against HeLa and MCF-7 cells than the corresponding ligand. |
| first_indexed | 2024-12-10T12:13:21Z |
| format | Article |
| id | doaj.art-d7942262894c4bdda79a0c9cc8d90253 |
| institution | Directory Open Access Journal |
| issn | 1927-7296 1927-730X |
| language | English |
| last_indexed | 2024-12-10T12:13:21Z |
| publishDate | 2019-06-01 |
| publisher | Growing Science |
| record_format | Article |
| series | Current Chemistry Letters |
| spelling | doaj.art-d7942262894c4bdda79a0c9cc8d902532022-12-22T01:49:17ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2019-06-018314515610.5267/j.ccl.2019.4.003Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligandSathiyaraj SubbaiyanIndhumathi PonnusamyNew ruthenium(III) complexes with 3-(Benzothiazol-2-yliminomethyl)-phenol (HL) ligand have been synthesized and characterized with the aid of elemental analysis, IR, electronic, and electron paramagnetic resonance spectroscopic techniques. The binding mode of the ligand and complexes with DNA and their ability to bind DNA have been investigated by UV-vis absorption titration. In addition, the ligand and complexes have been subjected to antioxidant activity tests which showed that HL and its ruthenium(III) complexes possess significant scavenging effect against DPPH and OH radicals. Cytotoxic activities of the ligand and ruthenium(III) complexes showed that the ruthenium(III) complexes exhibited more effective cytotoxic activity against HeLa and MCF-7 cells than the corresponding ligand.http://www.growingscience.com/ccl/Vol8/ccl_2019_13.pdfRuthenium(III) complexSchiff baseDNA-bindingScavenging activityIn vitro cytotoxicity |
| spellingShingle | Sathiyaraj Subbaiyan Indhumathi Ponnusamy Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligand Current Chemistry Letters Ruthenium(III) complex Schiff base DNA-binding Scavenging activity In vitro cytotoxicity |
| title | Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligand |
| title_full | Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligand |
| title_fullStr | Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligand |
| title_full_unstemmed | Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligand |
| title_short | Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligand |
| title_sort | biological investigations of ruthenium iii 3 benzothiazol 2 liminomethyl phenol schiff base complexes bearing pph3 asph3 coligand |
| topic | Ruthenium(III) complex Schiff base DNA-binding Scavenging activity In vitro cytotoxicity |
| url | http://www.growingscience.com/ccl/Vol8/ccl_2019_13.pdf |
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