Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy
<p>Abstract</p> <p>Background</p> <p>Few reports can be found in the literature with respect to the impact of neoadjuvant hormonal therapy (NHT) on operative parameters on laparoscopic radical prostatectomy (LRP) in a large study. The aim of this study was to evaluate t...
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| Format: | Article |
| Language: | English |
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BMC
2012-12-01
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| Series: | BMC Urology |
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| Online Access: | http://www.biomedcentral.com/1471-2490/12/36 |
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| author | Naiki Taku Kawai Noriyasu Okamura Takehiko Nagata Daisuke Kojima Yoshiyuki Akita Hidetoshi Yasui Takahiro Tozawa Keiichi Kohri Kenjiro |
| author_facet | Naiki Taku Kawai Noriyasu Okamura Takehiko Nagata Daisuke Kojima Yoshiyuki Akita Hidetoshi Yasui Takahiro Tozawa Keiichi Kohri Kenjiro |
| author_sort | Naiki Taku |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Few reports can be found in the literature with respect to the impact of neoadjuvant hormonal therapy (NHT) on operative parameters on laparoscopic radical prostatectomy (LRP) in a large study. The aim of this study was to evaluate the safety and efficacy of NHT prior to LRP for locally confined prostate cancer.</p> <p>Methods</p> <p>From January 2004 to September 2009, 342 patients undergoing LRP were analyzed, specifically comparing 72 patients who received NHT to 270 who did not. All patients were in clinical stage T2 and nerve sparing LRP were not included.</p> <p>Results</p> <p>The mean patient age, preoperative prostate specific antigen (PSA), clinical stage, and biopsy Gleason grade were similar for the NHT and the non-NHT LRP groups. The median blood loss and the median operative time were also similar. There were no differences in the intraoperative complication rate of rectum injury, blood transfusion, and open surgery conversion. The positive surgical margin rate was significantly improved in NHT patients. Moreover, PSA recurrence within two years was significantly less in long-term NHT than in non-NHT patients.</p> <p>Conclusions</p> <p>LRP was shown as a safe and efficacious procedure in patients who have received NHT. Perioperative morbidity of NHT patients undergoing LRP appears equivalent to non-NHT patients, with lower positive surgical margin, and PSA recurrence rate.</p> |
| first_indexed | 2024-12-18T10:21:40Z |
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| id | doaj.art-d795a909391845eea0d5a629ea9f3122 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-12-18T10:21:40Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-d795a909391845eea0d5a629ea9f31222022-12-21T21:11:07ZengBMCBMC Urology1471-24902012-12-011213610.1186/1471-2490-12-36Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomyNaiki TakuKawai NoriyasuOkamura TakehikoNagata DaisukeKojima YoshiyukiAkita HidetoshiYasui TakahiroTozawa KeiichiKohri Kenjiro<p>Abstract</p> <p>Background</p> <p>Few reports can be found in the literature with respect to the impact of neoadjuvant hormonal therapy (NHT) on operative parameters on laparoscopic radical prostatectomy (LRP) in a large study. The aim of this study was to evaluate the safety and efficacy of NHT prior to LRP for locally confined prostate cancer.</p> <p>Methods</p> <p>From January 2004 to September 2009, 342 patients undergoing LRP were analyzed, specifically comparing 72 patients who received NHT to 270 who did not. All patients were in clinical stage T2 and nerve sparing LRP were not included.</p> <p>Results</p> <p>The mean patient age, preoperative prostate specific antigen (PSA), clinical stage, and biopsy Gleason grade were similar for the NHT and the non-NHT LRP groups. The median blood loss and the median operative time were also similar. There were no differences in the intraoperative complication rate of rectum injury, blood transfusion, and open surgery conversion. The positive surgical margin rate was significantly improved in NHT patients. Moreover, PSA recurrence within two years was significantly less in long-term NHT than in non-NHT patients.</p> <p>Conclusions</p> <p>LRP was shown as a safe and efficacious procedure in patients who have received NHT. Perioperative morbidity of NHT patients undergoing LRP appears equivalent to non-NHT patients, with lower positive surgical margin, and PSA recurrence rate.</p>http://www.biomedcentral.com/1471-2490/12/36Prostate cancerNeoadjuvant hormonal therapyLaparoscopic radical prostatectomy |
| spellingShingle | Naiki Taku Kawai Noriyasu Okamura Takehiko Nagata Daisuke Kojima Yoshiyuki Akita Hidetoshi Yasui Takahiro Tozawa Keiichi Kohri Kenjiro Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy BMC Urology Prostate cancer Neoadjuvant hormonal therapy Laparoscopic radical prostatectomy |
| title | Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy |
| title_full | Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy |
| title_fullStr | Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy |
| title_full_unstemmed | Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy |
| title_short | Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy |
| title_sort | neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy |
| topic | Prostate cancer Neoadjuvant hormonal therapy Laparoscopic radical prostatectomy |
| url | http://www.biomedcentral.com/1471-2490/12/36 |
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