Mechanical Characterization of Brain Tissue in High-Rate Extension
Mechanical properties of brain tissue characterized in high-rate loading regime are indispensable for the analysis of traumatic brain injury (TBI). However, data on such properties are very limited. In this study, we measured transient response of brain tissue subjected to high-rate extension. A ser...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The Japan Society of Mechanical Engineers
2008-08-01
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| Series: | Journal of Biomechanical Science and Engineering |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jbse/3/2/3_2_263/_pdf/-char/en |
| _version_ | 1818532605775052800 |
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| author | Atsutaka TAMURA Sadayuki HAYASHI Kazuaki NAGAYAMA Takeo MATSUMOTO |
| author_facet | Atsutaka TAMURA Sadayuki HAYASHI Kazuaki NAGAYAMA Takeo MATSUMOTO |
| author_sort | Atsutaka TAMURA |
| collection | DOAJ |
| description | Mechanical properties of brain tissue characterized in high-rate loading regime are indispensable for the analysis of traumatic brain injury (TBI). However, data on such properties are very limited. In this study, we measured transient response of brain tissue subjected to high-rate extension. A series of uniaxial extension tests at strain rates ranging from 0.9 to 25 s-1 and stress relaxation tests following a step-like displacement to different strain levels (15-50%) were conducted in cylindrical specimens obtained from fresh porcine brains. A strong rate sensitivity was found in the brain tissue, i.e., initial elastic modulus was 4.2 ± 1.6, 7.7 ± 4.0, and 18.6 ± 3.6 kPa (mean ± SD) for a strain rate of 0.9, 4.3, and 25 s-1, respectively. In addition, the relaxation function was successfully approximated to be strain-time separable, i.e., material response can be expressed as a product of time-dependent and strain-dependent components as:K(t) = G(t)σe(ε), where G(t) is a reduced relaxation function, G(t) = 0.416e-t/0.0096+0.327e-t/0.0138+0.256e-t/1.508, and σe(ε) is the peak stress following a step input of ε. Results of the present study will improve biofidelity of computational models of a human head and provide useful information for the analysis of TBI under injurious environments with strain rates greater than 10 s-1. |
| first_indexed | 2024-12-11T17:47:43Z |
| format | Article |
| id | doaj.art-d79692d00dfb4f608bcedc2f28481a63 |
| institution | Directory Open Access Journal |
| issn | 1880-9863 |
| language | English |
| last_indexed | 2024-12-11T17:47:43Z |
| publishDate | 2008-08-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Journal of Biomechanical Science and Engineering |
| spelling | doaj.art-d79692d00dfb4f608bcedc2f28481a632022-12-22T00:56:20ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632008-08-013226327410.1299/jbse.3.263jbseMechanical Characterization of Brain Tissue in High-Rate ExtensionAtsutaka TAMURA0Sadayuki HAYASHI1Kazuaki NAGAYAMA2Takeo MATSUMOTO3Biomechanics Laboratory, Nagoya Institute of TechnologyBiomechanics Laboratory, Toyota Central R&D Labs., Inc.Biomechanics Laboratory, Nagoya Institute of TechnologyBiomechanics Laboratory, Nagoya Institute of TechnologyMechanical properties of brain tissue characterized in high-rate loading regime are indispensable for the analysis of traumatic brain injury (TBI). However, data on such properties are very limited. In this study, we measured transient response of brain tissue subjected to high-rate extension. A series of uniaxial extension tests at strain rates ranging from 0.9 to 25 s-1 and stress relaxation tests following a step-like displacement to different strain levels (15-50%) were conducted in cylindrical specimens obtained from fresh porcine brains. A strong rate sensitivity was found in the brain tissue, i.e., initial elastic modulus was 4.2 ± 1.6, 7.7 ± 4.0, and 18.6 ± 3.6 kPa (mean ± SD) for a strain rate of 0.9, 4.3, and 25 s-1, respectively. In addition, the relaxation function was successfully approximated to be strain-time separable, i.e., material response can be expressed as a product of time-dependent and strain-dependent components as:K(t) = G(t)σe(ε), where G(t) is a reduced relaxation function, G(t) = 0.416e-t/0.0096+0.327e-t/0.0138+0.256e-t/1.508, and σe(ε) is the peak stress following a step input of ε. Results of the present study will improve biofidelity of computational models of a human head and provide useful information for the analysis of TBI under injurious environments with strain rates greater than 10 s-1.https://www.jstage.jst.go.jp/article/jbse/3/2/3_2_263/_pdf/-char/enbrain tissuevisocoelasticitystressstrainhigh-rate extensionrelaxationtraumatic brain injury (tbi) |
| spellingShingle | Atsutaka TAMURA Sadayuki HAYASHI Kazuaki NAGAYAMA Takeo MATSUMOTO Mechanical Characterization of Brain Tissue in High-Rate Extension Journal of Biomechanical Science and Engineering brain tissue visocoelasticity stress strain high-rate extension relaxation traumatic brain injury (tbi) |
| title | Mechanical Characterization of Brain Tissue in High-Rate Extension |
| title_full | Mechanical Characterization of Brain Tissue in High-Rate Extension |
| title_fullStr | Mechanical Characterization of Brain Tissue in High-Rate Extension |
| title_full_unstemmed | Mechanical Characterization of Brain Tissue in High-Rate Extension |
| title_short | Mechanical Characterization of Brain Tissue in High-Rate Extension |
| title_sort | mechanical characterization of brain tissue in high rate extension |
| topic | brain tissue visocoelasticity stress strain high-rate extension relaxation traumatic brain injury (tbi) |
| url | https://www.jstage.jst.go.jp/article/jbse/3/2/3_2_263/_pdf/-char/en |
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