Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy
IntroductionBrain cortico-subcortical connectivity has been investigated in epilepsy using the functional MRI (MRI). Although structural images cannot demonstrate dynamic changes, they provide higher spatial resolution, which allows exploration of the organization of brain in greater detail.MethodsW...
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.810186/full |
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| author | Hsin Tung Hsin Tung Hsin Tung Szu-Yen Pan Tsuo-Hung Lan Tsuo-Hung Lan Tsuo-Hung Lan Tsuo-Hung Lan Yung-Yang Lin Yung-Yang Lin Yung-Yang Lin Syu-Jyun Peng |
| author_facet | Hsin Tung Hsin Tung Hsin Tung Szu-Yen Pan Tsuo-Hung Lan Tsuo-Hung Lan Tsuo-Hung Lan Tsuo-Hung Lan Yung-Yang Lin Yung-Yang Lin Yung-Yang Lin Syu-Jyun Peng |
| author_sort | Hsin Tung |
| collection | DOAJ |
| description | IntroductionBrain cortico-subcortical connectivity has been investigated in epilepsy using the functional MRI (MRI). Although structural images cannot demonstrate dynamic changes, they provide higher spatial resolution, which allows exploration of the organization of brain in greater detail.MethodsWe used high-resolution brain MRI to study the hippocampal-thalamic-cortical networks in temporal lobe epilepsy (TLE) using a volume-based morphometric method. We enrolled 22 right-TLE, 33 left-TLE, and 28 age/gender-matched controls retrospectively. FreeSurfer software was used for the thalamus segmentation.ResultsAmong the 50 subfields, ipsilateral anterior, lateral, and parts of the intralaminar and medial nuclei, as well as the contralateral parts of lateral nuclei had significant volume loss in both TLE. The anteroventral nucleus was most vulnerable. Most thalamic subfields were susceptible to seizure burden, especially the left-TLE. SPM12 was used to conduct an analysis of the gray matter density (GMD) maps. Decreased extratemporal GMD occurred bilaterally. Both TLE demonstrated significant GMD loss over the ipsilateral inferior frontal gyrus, precentral gyrus, and medial orbital cortices.SignificanceThalamic subfield atrophy was related to the ipsilateral inferior frontal GMD changes, which presented positively in left-TLE and negatively in right-TLE. These findings suggest prefrontal-thalamo-hippocampal network disruption in TLE. |
| first_indexed | 2024-12-13T13:07:58Z |
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| id | doaj.art-d79888d196f84d7cb1a781dbc62d3386 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-13T13:07:58Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-d79888d196f84d7cb1a781dbc62d33862022-12-21T23:44:46ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-02-011210.3389/fneur.2021.810186810186Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe EpilepsyHsin Tung0Hsin Tung1Hsin Tung2Szu-Yen Pan3Tsuo-Hung Lan4Tsuo-Hung Lan5Tsuo-Hung Lan6Tsuo-Hung Lan7Yung-Yang Lin8Yung-Yang Lin9Yung-Yang Lin10Syu-Jyun Peng11Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCenter of Faculty Development, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Epilepsy, Neurological Institute, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, TaiwanTsaotun Psychiatric Center, Ministry of Health and Welfare, Nantou, TaiwanDepartment of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCenter for Neuropsychiatric Research, National Health Research Institutes, Zhunan, TaiwanInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan0Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan1Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanIntroductionBrain cortico-subcortical connectivity has been investigated in epilepsy using the functional MRI (MRI). Although structural images cannot demonstrate dynamic changes, they provide higher spatial resolution, which allows exploration of the organization of brain in greater detail.MethodsWe used high-resolution brain MRI to study the hippocampal-thalamic-cortical networks in temporal lobe epilepsy (TLE) using a volume-based morphometric method. We enrolled 22 right-TLE, 33 left-TLE, and 28 age/gender-matched controls retrospectively. FreeSurfer software was used for the thalamus segmentation.ResultsAmong the 50 subfields, ipsilateral anterior, lateral, and parts of the intralaminar and medial nuclei, as well as the contralateral parts of lateral nuclei had significant volume loss in both TLE. The anteroventral nucleus was most vulnerable. Most thalamic subfields were susceptible to seizure burden, especially the left-TLE. SPM12 was used to conduct an analysis of the gray matter density (GMD) maps. Decreased extratemporal GMD occurred bilaterally. Both TLE demonstrated significant GMD loss over the ipsilateral inferior frontal gyrus, precentral gyrus, and medial orbital cortices.SignificanceThalamic subfield atrophy was related to the ipsilateral inferior frontal GMD changes, which presented positively in left-TLE and negatively in right-TLE. These findings suggest prefrontal-thalamo-hippocampal network disruption in TLE.https://www.frontiersin.org/articles/10.3389/fneur.2021.810186/fullgray matter densitythalamusanterior thalamic nucleushippocampal-thalamic-cortical networktemporal lobe epilepsy |
| spellingShingle | Hsin Tung Hsin Tung Hsin Tung Szu-Yen Pan Tsuo-Hung Lan Tsuo-Hung Lan Tsuo-Hung Lan Tsuo-Hung Lan Yung-Yang Lin Yung-Yang Lin Yung-Yang Lin Syu-Jyun Peng Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy Frontiers in Neurology gray matter density thalamus anterior thalamic nucleus hippocampal-thalamic-cortical network temporal lobe epilepsy |
| title | Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy |
| title_full | Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy |
| title_fullStr | Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy |
| title_full_unstemmed | Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy |
| title_short | Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy |
| title_sort | characterization of hippocampal thalamic cortical morphometric reorganization in temporal lobe epilepsy |
| topic | gray matter density thalamus anterior thalamic nucleus hippocampal-thalamic-cortical network temporal lobe epilepsy |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.810186/full |
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