<i>Agrocybe aegerita</i> Polysaccharide Combined with <i>Bifidobacterium lactis</i> Bb-12 Attenuates Aging-Related Oxidative Stress and Restores Gut Microbiota
The objective of this study was to examine the impacts of the combing of <i>Agrocybe aegerita</i> polysaccharides (AAPS) with <i>Bifidobacterium lactis</i> Bb-12 (Bb-12) on antioxidant activity, anti-aging properties, and modulation of gut microbiota. The results demonstrated...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/24/4381 |
| _version_ | 1797381149480189952 |
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| author | Xiaoyan Liu Yanyu Feng Hongmin Zhen Lina Zhao Hongqiang Wu Bin Liu Guangsen Fan Aijun Tong |
| author_facet | Xiaoyan Liu Yanyu Feng Hongmin Zhen Lina Zhao Hongqiang Wu Bin Liu Guangsen Fan Aijun Tong |
| author_sort | Xiaoyan Liu |
| collection | DOAJ |
| description | The objective of this study was to examine the impacts of the combing of <i>Agrocybe aegerita</i> polysaccharides (AAPS) with <i>Bifidobacterium lactis</i> Bb-12 (Bb-12) on antioxidant activity, anti-aging properties, and modulation of gut microbiota. The results demonstrated that the AAPS and Bb-12 complex significantly increased the average lifespan of male and female <i>Drosophila melanogaster</i> under natural aging conditions (<i>p</i> < 0.05), with an improvement of 8.42% and 9.79%, respectively. Additionally, the complex enhanced their climbing ability and increased antioxidant enzyme activity, protecting them from oxidative damage induced by H<sub>2</sub>O<sub>2</sub>. In D-galactose induced aging mice, the addition of AAPS and Bb-12 resulted in significantly increase in antioxidant enzyme activity, regulation of aging-related biomarker levels, changed gut microbiota diversity, restoration of microbial structure, and increased abundance of beneficial bacteria, particularly lactobacilli, in the intestines. These findings suggested that the complex of AAPS and Bb-12 had the potential to serve as a dietary supplement against organism aging and oxidative stress. |
| first_indexed | 2024-03-08T20:47:13Z |
| format | Article |
| id | doaj.art-d79913f9e2c74a0ca8b32f60d314e351 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-08T20:47:13Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-d79913f9e2c74a0ca8b32f60d314e3512023-12-22T14:08:28ZengMDPI AGFoods2304-81582023-12-011224438110.3390/foods12244381<i>Agrocybe aegerita</i> Polysaccharide Combined with <i>Bifidobacterium lactis</i> Bb-12 Attenuates Aging-Related Oxidative Stress and Restores Gut MicrobiotaXiaoyan Liu0Yanyu Feng1Hongmin Zhen2Lina Zhao3Hongqiang Wu4Bin Liu5Guangsen Fan6Aijun Tong7Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaBeijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaChina National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaBeijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaThe objective of this study was to examine the impacts of the combing of <i>Agrocybe aegerita</i> polysaccharides (AAPS) with <i>Bifidobacterium lactis</i> Bb-12 (Bb-12) on antioxidant activity, anti-aging properties, and modulation of gut microbiota. The results demonstrated that the AAPS and Bb-12 complex significantly increased the average lifespan of male and female <i>Drosophila melanogaster</i> under natural aging conditions (<i>p</i> < 0.05), with an improvement of 8.42% and 9.79%, respectively. Additionally, the complex enhanced their climbing ability and increased antioxidant enzyme activity, protecting them from oxidative damage induced by H<sub>2</sub>O<sub>2</sub>. In D-galactose induced aging mice, the addition of AAPS and Bb-12 resulted in significantly increase in antioxidant enzyme activity, regulation of aging-related biomarker levels, changed gut microbiota diversity, restoration of microbial structure, and increased abundance of beneficial bacteria, particularly lactobacilli, in the intestines. These findings suggested that the complex of AAPS and Bb-12 had the potential to serve as a dietary supplement against organism aging and oxidative stress.https://www.mdpi.com/2304-8158/12/24/4381<i>Agrocybe aegerita</i> polysaccharides<i>Bifidobacterium lactis</i> Bb-12antioxidantanti-aginggut microbiota |
| spellingShingle | Xiaoyan Liu Yanyu Feng Hongmin Zhen Lina Zhao Hongqiang Wu Bin Liu Guangsen Fan Aijun Tong <i>Agrocybe aegerita</i> Polysaccharide Combined with <i>Bifidobacterium lactis</i> Bb-12 Attenuates Aging-Related Oxidative Stress and Restores Gut Microbiota Foods <i>Agrocybe aegerita</i> polysaccharides <i>Bifidobacterium lactis</i> Bb-12 antioxidant anti-aging gut microbiota |
| title | <i>Agrocybe aegerita</i> Polysaccharide Combined with <i>Bifidobacterium lactis</i> Bb-12 Attenuates Aging-Related Oxidative Stress and Restores Gut Microbiota |
| title_full | <i>Agrocybe aegerita</i> Polysaccharide Combined with <i>Bifidobacterium lactis</i> Bb-12 Attenuates Aging-Related Oxidative Stress and Restores Gut Microbiota |
| title_fullStr | <i>Agrocybe aegerita</i> Polysaccharide Combined with <i>Bifidobacterium lactis</i> Bb-12 Attenuates Aging-Related Oxidative Stress and Restores Gut Microbiota |
| title_full_unstemmed | <i>Agrocybe aegerita</i> Polysaccharide Combined with <i>Bifidobacterium lactis</i> Bb-12 Attenuates Aging-Related Oxidative Stress and Restores Gut Microbiota |
| title_short | <i>Agrocybe aegerita</i> Polysaccharide Combined with <i>Bifidobacterium lactis</i> Bb-12 Attenuates Aging-Related Oxidative Stress and Restores Gut Microbiota |
| title_sort | i agrocybe aegerita i polysaccharide combined with i bifidobacterium lactis i bb 12 attenuates aging related oxidative stress and restores gut microbiota |
| topic | <i>Agrocybe aegerita</i> polysaccharides <i>Bifidobacterium lactis</i> Bb-12 antioxidant anti-aging gut microbiota |
| url | https://www.mdpi.com/2304-8158/12/24/4381 |
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