The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. <i>Diagnostics</i> 2021, <i>11</i>, 2171
Multicancer Early Detection (MCED) represents a new and exciting paradigm for the early detection of cancer, which is the leading cause of death worldwide. Current screening tests, recommended for only five cancer types (breast, lung, colon, cervical, and prostate), are limited by a lack of complete...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/5/1243 |
| _version_ | 1797500468326301696 |
|---|---|
| author | Eric A. Klein Tomasz M. Beer Michael Seiden |
| author_facet | Eric A. Klein Tomasz M. Beer Michael Seiden |
| author_sort | Eric A. Klein |
| collection | DOAJ |
| description | Multicancer Early Detection (MCED) represents a new and exciting paradigm for the early detection of cancer, which is the leading cause of death worldwide. Current screening tests, recommended for only five cancer types (breast, lung, colon, cervical, and prostate), are limited by a lack of complete adherence to guideline-based use and by the fact that they have cumulative high false positive rates. MCED tests agnostically detect cancer signals in the blood with good sensitivity and low false positive rates, can predict the cancer site of origin with high accuracy, can detect highly lethal cancers that have no current screening tests, and promise to improve cancer screening by improving efficiency and reducing the overall number needed to screen. Herein we outline this promise and clarify several published misconceptions about this field. |
| first_indexed | 2024-03-10T03:02:20Z |
| format | Article |
| id | doaj.art-d7991a9b496e40d1aa9ce888f8ba1ebf |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T03:02:20Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d7991a9b496e40d1aa9ce888f8ba1ebf2023-11-23T10:41:24ZengMDPI AGDiagnostics2075-44182022-05-01125124310.3390/diagnostics12051243The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. <i>Diagnostics</i> 2021, <i>11</i>, 2171Eric A. Klein0Tomasz M. Beer1Michael Seiden2Glickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Ave, Q10-1, Cleveland, OH 44195, USAKnight Cancer Institute, Oregon Health & Science University, CH-14R, 3303 SW Bond Ave, Portland, OR 97239, USAIndependent Researchers, Phialdelphia, PA 19111, USAMulticancer Early Detection (MCED) represents a new and exciting paradigm for the early detection of cancer, which is the leading cause of death worldwide. Current screening tests, recommended for only five cancer types (breast, lung, colon, cervical, and prostate), are limited by a lack of complete adherence to guideline-based use and by the fact that they have cumulative high false positive rates. MCED tests agnostically detect cancer signals in the blood with good sensitivity and low false positive rates, can predict the cancer site of origin with high accuracy, can detect highly lethal cancers that have no current screening tests, and promise to improve cancer screening by improving efficiency and reducing the overall number needed to screen. Herein we outline this promise and clarify several published misconceptions about this field.https://www.mdpi.com/2075-4418/12/5/1243multicancer early detectionmethylationcirculating cell-free genome atlas |
| spellingShingle | Eric A. Klein Tomasz M. Beer Michael Seiden The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. <i>Diagnostics</i> 2021, <i>11</i>, 2171 Diagnostics multicancer early detection methylation circulating cell-free genome atlas |
| title | The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. <i>Diagnostics</i> 2021, <i>11</i>, 2171 |
| title_full | The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. <i>Diagnostics</i> 2021, <i>11</i>, 2171 |
| title_fullStr | The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. <i>Diagnostics</i> 2021, <i>11</i>, 2171 |
| title_full_unstemmed | The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. <i>Diagnostics</i> 2021, <i>11</i>, 2171 |
| title_short | The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. <i>Diagnostics</i> 2021, <i>11</i>, 2171 |
| title_sort | promise of multicancer early detection comment on pons belda et al can circulating tumor dna support a successful screening test for early cancer detection the grail paradigm i diagnostics i 2021 i 11 i 2171 |
| topic | multicancer early detection methylation circulating cell-free genome atlas |
| url | https://www.mdpi.com/2075-4418/12/5/1243 |
| work_keys_str_mv | AT ericaklein thepromiseofmulticancerearlydetectioncommentonponsbeldaetalcancirculatingtumordnasupportasuccessfulscreeningtestforearlycancerdetectionthegrailparadigmidiagnosticsi2021i11i2171 AT tomaszmbeer thepromiseofmulticancerearlydetectioncommentonponsbeldaetalcancirculatingtumordnasupportasuccessfulscreeningtestforearlycancerdetectionthegrailparadigmidiagnosticsi2021i11i2171 AT michaelseiden thepromiseofmulticancerearlydetectioncommentonponsbeldaetalcancirculatingtumordnasupportasuccessfulscreeningtestforearlycancerdetectionthegrailparadigmidiagnosticsi2021i11i2171 AT ericaklein promiseofmulticancerearlydetectioncommentonponsbeldaetalcancirculatingtumordnasupportasuccessfulscreeningtestforearlycancerdetectionthegrailparadigmidiagnosticsi2021i11i2171 AT tomaszmbeer promiseofmulticancerearlydetectioncommentonponsbeldaetalcancirculatingtumordnasupportasuccessfulscreeningtestforearlycancerdetectionthegrailparadigmidiagnosticsi2021i11i2171 AT michaelseiden promiseofmulticancerearlydetectioncommentonponsbeldaetalcancirculatingtumordnasupportasuccessfulscreeningtestforearlycancerdetectionthegrailparadigmidiagnosticsi2021i11i2171 |