The Relationship Between Insulin PSTI Polymorphism and Prostate Cancer in Turkish Population
Purpose: There is positive correlation between insulin and various cancers such as colon, lung and endometrium. Protate cancer is the one of them. The aim of this study, to determine the incidance of INS+1127 PstI polymorphism, located in the 3’ UTR of insulin gene, between prostate cancer...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cukurova University
2013-06-01
|
| Series: | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | http://www.scopemed.org/fulltextpdf.php?mno=28172 |
| _version_ | 1797924144854073344 |
|---|---|
| author | Muhammed Hamza Muslumanoglu Tanju Basmaci Selma Demir Ulusal Huseyin Aslan Emre Tepeli Muhsin Ozdemir Mehmet Turgut |
| author_facet | Muhammed Hamza Muslumanoglu Tanju Basmaci Selma Demir Ulusal Huseyin Aslan Emre Tepeli Muhsin Ozdemir Mehmet Turgut |
| author_sort | Muhammed Hamza Muslumanoglu |
| collection | DOAJ |
| description | Purpose: There is positive correlation between insulin and various cancers such as colon, lung and endometrium. Protate cancer is the one of them. The aim of this study, to determine the incidance of INS+1127 PstI polymorphism, located in the 3’ UTR of insulin gene, between prostate cancer cases and controls and to clarify if this polymorphism have any role in the etiology of prostate cancer. Methods: We investigated 71 prostate cancer cases and 119 normal controls unrelated to patients. INS+1127 PstI polymorphism was investigated with PCR and RFLP method. Results: At the end of study; INS+1127 PstI polymorphism genotypes out to be 67.6 % CC, 28.2 % CT, 4.2 % TT among prostatic cancer individuals and 78.2% CC, 21% CT, 0.8% TT among control group individuals. Conclusion: As a result, there was no significant difference between patients and control group, in the genotype distribution. [Cukurova Med J 2013; 38(3.000): 434-439] |
| first_indexed | 2024-04-10T14:57:00Z |
| format | Article |
| id | doaj.art-d799b1687bd54357aede100dedc54d1b |
| institution | Directory Open Access Journal |
| issn | 0250-5150 |
| language | English |
| last_indexed | 2024-04-10T14:57:00Z |
| publishDate | 2013-06-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| spelling | doaj.art-d799b1687bd54357aede100dedc54d1b2023-02-15T16:07:19ZengCukurova UniversityÇukurova Üniversitesi Tıp Fakültesi Dergisi0250-51502013-06-01383434439The Relationship Between Insulin PSTI Polymorphism and Prostate Cancer in Turkish PopulationMuhammed Hamza MuslumanogluTanju BasmaciSelma Demir UlusalHuseyin AslanEmre TepeliMuhsin OzdemirMehmet TurgutPurpose: There is positive correlation between insulin and various cancers such as colon, lung and endometrium. Protate cancer is the one of them. The aim of this study, to determine the incidance of INS+1127 PstI polymorphism, located in the 3’ UTR of insulin gene, between prostate cancer cases and controls and to clarify if this polymorphism have any role in the etiology of prostate cancer. Methods: We investigated 71 prostate cancer cases and 119 normal controls unrelated to patients. INS+1127 PstI polymorphism was investigated with PCR and RFLP method. Results: At the end of study; INS+1127 PstI polymorphism genotypes out to be 67.6 % CC, 28.2 % CT, 4.2 % TT among prostatic cancer individuals and 78.2% CC, 21% CT, 0.8% TT among control group individuals. Conclusion: As a result, there was no significant difference between patients and control group, in the genotype distribution. [Cukurova Med J 2013; 38(3.000): 434-439]http://www.scopemed.org/fulltextpdf.php?mno=28172INSpolymorphismprostate cancerPstI |
| spellingShingle | Muhammed Hamza Muslumanoglu Tanju Basmaci Selma Demir Ulusal Huseyin Aslan Emre Tepeli Muhsin Ozdemir Mehmet Turgut The Relationship Between Insulin PSTI Polymorphism and Prostate Cancer in Turkish Population Çukurova Üniversitesi Tıp Fakültesi Dergisi INS polymorphism prostate cancer PstI |
| title | The Relationship Between Insulin PSTI Polymorphism and Prostate Cancer in Turkish Population |
| title_full | The Relationship Between Insulin PSTI Polymorphism and Prostate Cancer in Turkish Population |
| title_fullStr | The Relationship Between Insulin PSTI Polymorphism and Prostate Cancer in Turkish Population |
| title_full_unstemmed | The Relationship Between Insulin PSTI Polymorphism and Prostate Cancer in Turkish Population |
| title_short | The Relationship Between Insulin PSTI Polymorphism and Prostate Cancer in Turkish Population |
| title_sort | relationship between insulin psti polymorphism and prostate cancer in turkish population |
| topic | INS polymorphism prostate cancer PstI |
| url | http://www.scopemed.org/fulltextpdf.php?mno=28172 |
| work_keys_str_mv | AT muhammedhamzamuslumanoglu therelationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT tanjubasmaci therelationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT selmademirulusal therelationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT huseyinaslan therelationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT emretepeli therelationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT muhsinozdemir therelationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT mehmetturgut therelationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT muhammedhamzamuslumanoglu relationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT tanjubasmaci relationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT selmademirulusal relationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT huseyinaslan relationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT emretepeli relationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT muhsinozdemir relationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation AT mehmetturgut relationshipbetweeninsulinpstipolymorphismandprostatecancerinturkishpopulation |