The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats
Predator exposure is a life-threatening experience and elicits learned fear responses to the context in which the predator was encountered. The anterior cingulate area (ACA) occupies a pivotal position in a cortical network responsive to predatory threats, and it exerts a critical role in processing...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/67007 |
| _version_ | 1811199888773349376 |
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| author | Miguel Antonio Xavier de Lima Marcus Vinicius C Baldo Fernando A Oliveira Newton Sabino Canteras |
| author_facet | Miguel Antonio Xavier de Lima Marcus Vinicius C Baldo Fernando A Oliveira Newton Sabino Canteras |
| author_sort | Miguel Antonio Xavier de Lima |
| collection | DOAJ |
| description | Predator exposure is a life-threatening experience and elicits learned fear responses to the context in which the predator was encountered. The anterior cingulate area (ACA) occupies a pivotal position in a cortical network responsive to predatory threats, and it exerts a critical role in processing fear memory. The experiments were made in mice and revealed that the ACA is involved in both the acquisition and expression of contextual fear to predatory threat. Overall, the ACA can provide predictive relationships between the context and the predator threat and influences fear memory acquisition through projections to the basolateral amygdala and perirhinal region and the expression of contextual fear through projections to the dorsolateral periaqueductal gray. Our results expand previous studies based on classical fear conditioning and open interesting perspectives for understanding how the ACA is involved in processing contextual fear memory to ethologic threatening conditions that entrain specific medial hypothalamic fear circuits. |
| first_indexed | 2024-04-12T01:55:18Z |
| format | Article |
| id | doaj.art-d799b60a3f9a4c688011300ed0fe20fd |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:55:18Z |
| publishDate | 2022-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d799b60a3f9a4c688011300ed0fe20fd2022-12-22T03:52:49ZengeLife Sciences Publications LtdeLife2050-084X2022-01-011110.7554/eLife.67007The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threatsMiguel Antonio Xavier de Lima0Marcus Vinicius C Baldo1Fernando A Oliveira2https://orcid.org/0000-0002-1632-4267Newton Sabino Canteras3https://orcid.org/0000-0002-7205-5372Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, BrazilDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, BrazilCellular and Molecular Neurobiology Laboratory (LaNeC) - Center for Mathematics, Computing and Cognition (CMCC), Federal University of ABC, São Bernardo do Campo, BrazilDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, BrazilPredator exposure is a life-threatening experience and elicits learned fear responses to the context in which the predator was encountered. The anterior cingulate area (ACA) occupies a pivotal position in a cortical network responsive to predatory threats, and it exerts a critical role in processing fear memory. The experiments were made in mice and revealed that the ACA is involved in both the acquisition and expression of contextual fear to predatory threat. Overall, the ACA can provide predictive relationships between the context and the predator threat and influences fear memory acquisition through projections to the basolateral amygdala and perirhinal region and the expression of contextual fear through projections to the dorsolateral periaqueductal gray. Our results expand previous studies based on classical fear conditioning and open interesting perspectives for understanding how the ACA is involved in processing contextual fear memory to ethologic threatening conditions that entrain specific medial hypothalamic fear circuits.https://elifesciences.org/articles/67007fear memorycerebral cortexdefensive behavior |
| spellingShingle | Miguel Antonio Xavier de Lima Marcus Vinicius C Baldo Fernando A Oliveira Newton Sabino Canteras The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats eLife fear memory cerebral cortex defensive behavior |
| title | The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats |
| title_full | The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats |
| title_fullStr | The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats |
| title_full_unstemmed | The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats |
| title_short | The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats |
| title_sort | anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats |
| topic | fear memory cerebral cortex defensive behavior |
| url | https://elifesciences.org/articles/67007 |
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