The Use of Ellagic Acid and <i>Annona muricata</i> Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot Study
<i>Background</i>: Human papilloma virus (HPV) has been recognized as one of the most common sexually transmitted infections and has been correlated with poor semen quality and male hypofertility. Ellagic acid and <i>Annona muricate</i> have been considered as fascinating com...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Online Access: | https://www.mdpi.com/2673-4397/2/3/20 |
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| author | Tommaso Cai Daniele Tiscione Marco Puglisi Luca Gallelli Manuela Colosimo Michele Rizzo Giovanni Liguori Sandra Mazzoli Alessandro Palmieri |
| author_facet | Tommaso Cai Daniele Tiscione Marco Puglisi Luca Gallelli Manuela Colosimo Michele Rizzo Giovanni Liguori Sandra Mazzoli Alessandro Palmieri |
| author_sort | Tommaso Cai |
| collection | DOAJ |
| description | <i>Background</i>: Human papilloma virus (HPV) has been recognized as one of the most common sexually transmitted infections and has been correlated with poor semen quality and male hypofertility. Ellagic acid and <i>Annona muricate</i> have been considered as fascinating compounds in the chemoprevention of HPV-related lesions of the cervix. Here, we aimed to evaluate the role of ellagic acid and <i>Annona muricata</i> (OASIT-k<sup>®</sup>) in managing male subjects with oligospermia and HPV-related infections. <i>Methods</i>: From January 2017 to January 2019, all patients attending our center for oligospermia were evaluated for HPV-DNA. All HPV-DNA positive patients underwent orally administered OASIT-k 1 tablet/day for 3 months. After 6 months, all patients underwent spermiogram, HPV-DNA analysis on seminal plasma and urological visit. The main outcome measures were HPV-DNA clearance rate and improvement of semen parameters. <i>Results</i>: Forty-three patients (aged 22–43 years) were enrolled and treated. At the end of the treatment, the clearance of HPV-DNA infections was 62.7% (27/43). Seminal parameters were improved by treatment in terms of the number of spermatozoa (10.6 vs. 15.8) and mobility (27.5% vs. 36.1%). <i>Conclusions</i>: The therapy with OASIT-K was efficient in improving the HPV-DNA clearance and seminal parameters. These promising data emphasize the importance of redirecting the immune responses in viral infections. |
| first_indexed | 2024-03-09T22:18:38Z |
| format | Article |
| id | doaj.art-d79a181d508844cd8099abe8bc01bcb1 |
| institution | Directory Open Access Journal |
| issn | 2673-4397 |
| language | English |
| last_indexed | 2024-03-09T22:18:38Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Uro |
| spelling | doaj.art-d79a181d508844cd8099abe8bc01bcb12023-11-23T19:19:52ZengMDPI AGUro2673-43972022-07-012316617210.3390/uro2030020The Use of Ellagic Acid and <i>Annona muricata</i> Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot StudyTommaso Cai0Daniele Tiscione1Marco Puglisi2Luca Gallelli3Manuela Colosimo4Michele Rizzo5Giovanni Liguori6Sandra Mazzoli7Alessandro Palmieri8Department of Urology, Santa Chiara Regional Hospital, Largo Medaglie d’Oro, 9, 38123 Trento, ItalyDepartment of Urology, Santa Chiara Regional Hospital, Largo Medaglie d’Oro, 9, 38123 Trento, ItalyDepartment of Urology, Santa Chiara Regional Hospital, Largo Medaglie d’Oro, 9, 38123 Trento, ItalyDepartment of Health Science, University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Service, Operative Unit of Microbiology and Virology, Pugliese Ciaccio Hospital, 88100 Catanzaro, ItalyDepartment of Urology, University of Trieste, 34121 Trieste, ItalyDepartment of Urology, University of Trieste, 34121 Trieste, ItalySTDs Centre, Santa Maria Annunziata Hospital, 50100 Florence, ItalyDepartment of Urology, University of Naples, Federico II, 80100 Naples, Italy<i>Background</i>: Human papilloma virus (HPV) has been recognized as one of the most common sexually transmitted infections and has been correlated with poor semen quality and male hypofertility. Ellagic acid and <i>Annona muricate</i> have been considered as fascinating compounds in the chemoprevention of HPV-related lesions of the cervix. Here, we aimed to evaluate the role of ellagic acid and <i>Annona muricata</i> (OASIT-k<sup>®</sup>) in managing male subjects with oligospermia and HPV-related infections. <i>Methods</i>: From January 2017 to January 2019, all patients attending our center for oligospermia were evaluated for HPV-DNA. All HPV-DNA positive patients underwent orally administered OASIT-k 1 tablet/day for 3 months. After 6 months, all patients underwent spermiogram, HPV-DNA analysis on seminal plasma and urological visit. The main outcome measures were HPV-DNA clearance rate and improvement of semen parameters. <i>Results</i>: Forty-three patients (aged 22–43 years) were enrolled and treated. At the end of the treatment, the clearance of HPV-DNA infections was 62.7% (27/43). Seminal parameters were improved by treatment in terms of the number of spermatozoa (10.6 vs. 15.8) and mobility (27.5% vs. 36.1%). <i>Conclusions</i>: The therapy with OASIT-K was efficient in improving the HPV-DNA clearance and seminal parameters. These promising data emphasize the importance of redirecting the immune responses in viral infections.https://www.mdpi.com/2673-4397/2/3/20human papilloma virusmale fertilityHPV-DNAellagic acid<i>Annona muricate</i> |
| spellingShingle | Tommaso Cai Daniele Tiscione Marco Puglisi Luca Gallelli Manuela Colosimo Michele Rizzo Giovanni Liguori Sandra Mazzoli Alessandro Palmieri The Use of Ellagic Acid and <i>Annona muricata</i> Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot Study Uro human papilloma virus male fertility HPV-DNA ellagic acid <i>Annona muricate</i> |
| title | The Use of Ellagic Acid and <i>Annona muricata</i> Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot Study |
| title_full | The Use of Ellagic Acid and <i>Annona muricata</i> Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot Study |
| title_fullStr | The Use of Ellagic Acid and <i>Annona muricata</i> Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot Study |
| title_full_unstemmed | The Use of Ellagic Acid and <i>Annona muricata</i> Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot Study |
| title_short | The Use of Ellagic Acid and <i>Annona muricata</i> Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot Study |
| title_sort | use of ellagic acid and i annona muricata i complex in male subjects with oligospermia and hpv related infections results from a pilot study |
| topic | human papilloma virus male fertility HPV-DNA ellagic acid <i>Annona muricate</i> |
| url | https://www.mdpi.com/2673-4397/2/3/20 |
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