Whole-Genome Analysis of Porcine Circovirus Type 2 in Russia
Porcine circovirus type 2 (PCV2) is the causative agent of porcine circovirus-associated diseases (PCVAD) that bring about significant economic losses in the pig industry all over the world. The aim of this study was to investigate the genetic diversity of PCV2 in Russia and characterize the availab...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/10/12/1631 |
| _version_ | 1797501670323650560 |
|---|---|
| author | Sergei Raev Anton Yuzhakov Taras Aliper |
| author_facet | Sergei Raev Anton Yuzhakov Taras Aliper |
| author_sort | Sergei Raev |
| collection | DOAJ |
| description | Porcine circovirus type 2 (PCV2) is the causative agent of porcine circovirus-associated diseases (PCVAD) that bring about significant economic losses in the pig industry all over the world. The aim of this study was to investigate the genetic diversity of PCV2 in Russia and characterize the available complete genome sequences. PCV2 DNA was detected at all investigated farms located in different regions of Russia. Whole-genome analysis demonstrated that the majority of PCV2 strains belonged to genotype PCV2d (12 out of 14), while PCV2a and PCV2b were only detected at 2 farms (one at each). Further analysis revealed that all antibody recognition sites in Russian PCV2 strains were different from the corresponding epitopes in a PCV2a vaccine strain, suggesting that PCV2a-based vaccines may only provide limited protection against these strains. PCV2d strains could be grouped into 3 distinct lines which shared 98.7–100% identity within open reading frame 2 (ORF2). It is the first study reporting the genetic diversity of PCV2 strains in Russia. Our data indicated that, similarly to China, Europe, and USA, PCV2a and PCV2b have largely been replaced by PCV2d. |
| first_indexed | 2024-03-10T03:21:53Z |
| format | Article |
| id | doaj.art-d79ac2d9d4654faeb549ddd91e781dab |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T03:21:53Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-d79ac2d9d4654faeb549ddd91e781dab2023-11-23T10:01:46ZengMDPI AGPathogens2076-08172021-12-011012163110.3390/pathogens10121631Whole-Genome Analysis of Porcine Circovirus Type 2 in RussiaSergei Raev0Anton Yuzhakov1Taras Aliper2Federal State Budget Scientific Institution “Federal Scientific Center VIEV”, 109428 Moscow, RussiaFederal State Budget Scientific Institution “Federal Scientific Center VIEV”, 109428 Moscow, RussiaFederal State Budget Scientific Institution “Federal Scientific Center VIEV”, 109428 Moscow, RussiaPorcine circovirus type 2 (PCV2) is the causative agent of porcine circovirus-associated diseases (PCVAD) that bring about significant economic losses in the pig industry all over the world. The aim of this study was to investigate the genetic diversity of PCV2 in Russia and characterize the available complete genome sequences. PCV2 DNA was detected at all investigated farms located in different regions of Russia. Whole-genome analysis demonstrated that the majority of PCV2 strains belonged to genotype PCV2d (12 out of 14), while PCV2a and PCV2b were only detected at 2 farms (one at each). Further analysis revealed that all antibody recognition sites in Russian PCV2 strains were different from the corresponding epitopes in a PCV2a vaccine strain, suggesting that PCV2a-based vaccines may only provide limited protection against these strains. PCV2d strains could be grouped into 3 distinct lines which shared 98.7–100% identity within open reading frame 2 (ORF2). It is the first study reporting the genetic diversity of PCV2 strains in Russia. Our data indicated that, similarly to China, Europe, and USA, PCV2a and PCV2b have largely been replaced by PCV2d.https://www.mdpi.com/2076-0817/10/12/1631porcine circovirus type 2genetic diversitygenotypesphylogenetic analysisPCV-2d |
| spellingShingle | Sergei Raev Anton Yuzhakov Taras Aliper Whole-Genome Analysis of Porcine Circovirus Type 2 in Russia Pathogens porcine circovirus type 2 genetic diversity genotypes phylogenetic analysis PCV-2d |
| title | Whole-Genome Analysis of Porcine Circovirus Type 2 in Russia |
| title_full | Whole-Genome Analysis of Porcine Circovirus Type 2 in Russia |
| title_fullStr | Whole-Genome Analysis of Porcine Circovirus Type 2 in Russia |
| title_full_unstemmed | Whole-Genome Analysis of Porcine Circovirus Type 2 in Russia |
| title_short | Whole-Genome Analysis of Porcine Circovirus Type 2 in Russia |
| title_sort | whole genome analysis of porcine circovirus type 2 in russia |
| topic | porcine circovirus type 2 genetic diversity genotypes phylogenetic analysis PCV-2d |
| url | https://www.mdpi.com/2076-0817/10/12/1631 |
| work_keys_str_mv | AT sergeiraev wholegenomeanalysisofporcinecircovirustype2inrussia AT antonyuzhakov wholegenomeanalysisofporcinecircovirustype2inrussia AT tarasaliper wholegenomeanalysisofporcinecircovirustype2inrussia |