The Effects of Serum and Follicular Fluid Vitamin D Levels on Assisted Reproductive Techniques: A Prospective Cohort Study
Background: Based on studies on animal models, vitamin D plays an essential role in reproduction by controllingCa and Mg levels. Despite these findings, the effects of vitamin D deficiency and supplementation on the outcome ofassisted reproductive techniques (ART) remain controversial. Therefore, th...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2021-10-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | https://www.ijfs.ir/article_243979_9ccf633b73b769a01c5386d2fd242ce9.pdf |
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| author | Ghazal Neysanian Moahboubeh Taebi Atefeh Rezaeian Mohammad Hossein Nasr-Esfahani Maryam Jahangirifar |
| author_facet | Ghazal Neysanian Moahboubeh Taebi Atefeh Rezaeian Mohammad Hossein Nasr-Esfahani Maryam Jahangirifar |
| author_sort | Ghazal Neysanian |
| collection | DOAJ |
| description | Background: Based on studies on animal models, vitamin D plays an essential role in reproduction by controllingCa and Mg levels. Despite these findings, the effects of vitamin D deficiency and supplementation on the outcome ofassisted reproductive techniques (ART) remain controversial. Therefore, the aim of the present study was to assess therelationship between serum and follicular fluid 25-OH vitamin D levels on reproductive outcomes of infertile women.Materials and Methods: This prospective cohort study included 150 infertile women who underwent in vitro fertilization(IVF) or intracytoplasmic sperm injection (ICSI). The participants were allocated to one of the three groups accordingto their serum and follicular fluid 25-OH vitamin D concentrations (less than 10 ng/ml, between 10 and 30 ng/ml and more than 30 ng/ml), and fertilization, cleavage and biochemical and clinical pregnancy rates were compared among the groups. Data was analyzed by SPSS software and using Chi-square and Spearman correlation coefficient.Results: Serum and follicular fluid vitamin D levels significantly correlated with biochemical (P=0.008), (P=0.003)and clinical pregnancy (P=0.017), (P=0.001) rates respectively . However, the quality of embryos (P=0.125), (P=0.106)and fertilization rate (P=0.082), (P=0.059) were not associated with the level of serum and follicular fluid vitamin D.Conclusion: This study found that women with higher levels of vitamin D in their serum and follicular fluid are significantly more likely to achieve pregnancy but without affecting the quality of embryo and fertility rate. |
| first_indexed | 2024-12-22T03:20:04Z |
| format | Article |
| id | doaj.art-d79b4c51c5654f68a4d5d6b971607f3f |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-22T03:20:04Z |
| publishDate | 2021-10-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-d79b4c51c5654f68a4d5d6b971607f3f2022-12-21T18:40:45ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782021-10-0115428028510.22074/ijfs.2021.138605.1033243979The Effects of Serum and Follicular Fluid Vitamin D Levels on Assisted Reproductive Techniques: A Prospective Cohort StudyGhazal Neysanian0Moahboubeh Taebi1Atefeh Rezaeian2Mohammad Hossein Nasr-Esfahani3Maryam Jahangirifar4Department of Midwifery and Reproductive Health, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Midwifery and Reproductive Health, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranDepartment of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran Isfahan Fertility and Infertility Center, Isfahan, IranSchool of Nursing and Midwifery, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, AustraliaBackground: Based on studies on animal models, vitamin D plays an essential role in reproduction by controllingCa and Mg levels. Despite these findings, the effects of vitamin D deficiency and supplementation on the outcome ofassisted reproductive techniques (ART) remain controversial. Therefore, the aim of the present study was to assess therelationship between serum and follicular fluid 25-OH vitamin D levels on reproductive outcomes of infertile women.Materials and Methods: This prospective cohort study included 150 infertile women who underwent in vitro fertilization(IVF) or intracytoplasmic sperm injection (ICSI). The participants were allocated to one of the three groups accordingto their serum and follicular fluid 25-OH vitamin D concentrations (less than 10 ng/ml, between 10 and 30 ng/ml and more than 30 ng/ml), and fertilization, cleavage and biochemical and clinical pregnancy rates were compared among the groups. Data was analyzed by SPSS software and using Chi-square and Spearman correlation coefficient.Results: Serum and follicular fluid vitamin D levels significantly correlated with biochemical (P=0.008), (P=0.003)and clinical pregnancy (P=0.017), (P=0.001) rates respectively . However, the quality of embryos (P=0.125), (P=0.106)and fertilization rate (P=0.082), (P=0.059) were not associated with the level of serum and follicular fluid vitamin D.Conclusion: This study found that women with higher levels of vitamin D in their serum and follicular fluid are significantly more likely to achieve pregnancy but without affecting the quality of embryo and fertility rate.https://www.ijfs.ir/article_243979_9ccf633b73b769a01c5386d2fd242ce9.pdfassisted reproductive techniquesfollicular fluidinfertilityserumvitamin d |
| spellingShingle | Ghazal Neysanian Moahboubeh Taebi Atefeh Rezaeian Mohammad Hossein Nasr-Esfahani Maryam Jahangirifar The Effects of Serum and Follicular Fluid Vitamin D Levels on Assisted Reproductive Techniques: A Prospective Cohort Study International Journal of Fertility and Sterility assisted reproductive techniques follicular fluid infertility serum vitamin d |
| title | The Effects of Serum and Follicular Fluid Vitamin D Levels on Assisted Reproductive Techniques: A Prospective Cohort Study |
| title_full | The Effects of Serum and Follicular Fluid Vitamin D Levels on Assisted Reproductive Techniques: A Prospective Cohort Study |
| title_fullStr | The Effects of Serum and Follicular Fluid Vitamin D Levels on Assisted Reproductive Techniques: A Prospective Cohort Study |
| title_full_unstemmed | The Effects of Serum and Follicular Fluid Vitamin D Levels on Assisted Reproductive Techniques: A Prospective Cohort Study |
| title_short | The Effects of Serum and Follicular Fluid Vitamin D Levels on Assisted Reproductive Techniques: A Prospective Cohort Study |
| title_sort | effects of serum and follicular fluid vitamin d levels on assisted reproductive techniques a prospective cohort study |
| topic | assisted reproductive techniques follicular fluid infertility serum vitamin d |
| url | https://www.ijfs.ir/article_243979_9ccf633b73b769a01c5386d2fd242ce9.pdf |
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