Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents

Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents

This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (5...

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Bibliographic Details
Main Authors: Katharinne I Moraes de Carvalho, Hélio B Fernandes, Flávia D Frota Machado, Irisdalva S Oliveira, Francisco A Oliveira, Paulo Humberto M Nunes, Julianeli T Lima, Jackson R G Silva Almeida, Rita C Meneses Oliveira
Format: Article
Language:English
Published: BMC 2010-01-01
Series:Biological Research
Subjects:
antioxidant
antiulcer activity
Encholirium spectabile
Bromeliaceae
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400011
Description
Summary:This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75 %), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.
ISSN:0716-9760
0717-6287

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