CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

Abstract Background B-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains. Among the BH domains, the BH3 domain is considered as a potent ‘death domain’ while the BH4 domain is required for anti-apoptotic activity. Bcl-2...

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Main Authors: Yihua Lin, Yiling Zhao, Minggui Chen, Zishuo Li, Qiao Liu, Jian Chen, Yi Ding, Chunyong Ding, Ye Ding, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Jia Zhou, Lijing Wang, Qian-Qian Zhang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Cancer
Subjects:
CYD0281
B-cell lymphoma 2 (Bcl-2)
Bcl-2 homology (BH) domains
BH4 domain antagonist
Apoptosis
Angiogenesis
Online Access:https://doi.org/10.1186/s12885-023-10974-4

Internet

https://doi.org/10.1186/s12885-023-10974-4

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