The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae

The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae

Arachidonic acid lipoxygenases (ALOXs) have been implicated in the immune response of mammals. The reaction specificity of these enzymes is decisive for their biological functions and ALOX classification is based on this enzyme property. Comparing the amino acid sequences and the functional properti...

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Bibliographic Details
Main Authors: Dagmar Heydeck, Florian Reisch, Marjann Schäfer, Kumar R. Kakularam, Sophie A. Roigas, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
eicosanoids
lipid peroxidation
oxidative stress
recombinant proteins
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.871585/full

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