The Reno and Hepatoprotective Effects of SAMWA Plant (Cleome droserifolia) Methanolic Extract against Adrenaline-Induced Adverse Effect to Male Rats
Adrenaline is widely used drug to combat several conditions such as allergy and anaphylaxis. The current work was to investigate the renal and hepatic complications following adrenaline injection, in addition, the impact of Cleome (SAMWA) methanolic extract on adrenaline- induced renal and hepatic...
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| Format: | Article |
| Language: | English |
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Assiut University
2024-01-01
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| Series: | Journal of Advanced Veterinary Research |
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| Online Access: | https://www.advetresearch.com/index.php/AVR/article/view/1666 |
| _version_ | 1797356980954726400 |
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| author | Sahar A. Abou Haleka Hanan M. Rashwan Hala M. Ebaid Heba N. Gad El Hak Dima Alkadri Heba M.A. Abdelrazek |
| author_facet | Sahar A. Abou Haleka Hanan M. Rashwan Hala M. Ebaid Heba N. Gad El Hak Dima Alkadri Heba M.A. Abdelrazek |
| author_sort | Sahar A. Abou Haleka |
| collection | DOAJ |
| description |
Adrenaline is widely used drug to combat several conditions such as allergy and anaphylaxis. The current work was to investigate the renal and hepatic complications following adrenaline injection, in addition, the impact of Cleome (SAMWA) methanolic extract on adrenaline- induced renal and hepatic alterations. Twenty-four male Wister rats were divided equally into four groups; Normal control group received oral distilled water for 30 consecutive days and administered subcutaneous saline on the 31st and 32nd days. The Cleome extract (200 mg/kg) group received Cleome methanolic extract (200 mg/kg, P.O) for 30 consecutive days and administered subcutaneous saline on the 31st and 32nd days. The adrenaline group received distilled water orally for 30 consecutive days and administered subcutaneous adrenaline (2 mg/kg, s.c.) divided into two doses (1 mg/kg, s.c) each on the 31st and 32nd days. Cleome extract (200 mg/kg)/ adrenaline received Cleome methanolic extract (200 mg/kg, P. O) for 30 consecutive days and administered subcutaneous adrenaline (2 mg/kg, s.c.) divided into two doses (1 mg/kg, s.c) each on the 31st and 32nd days. Liver and kidney function biomarkers in addition to histopathological analyses were evaluated. Adrenaline caused alteration in liver and kidney function biomarkers without affecting the histological structure of the liver and the kidney. SAMWA methanolic extract pretreatment significantly decreased serum urea, uric acid, aspartate aminotransferase (AST), alanine transaminase (ALT) and Alkaline Phosphatase (ALP). SAMWA ameliorated serum albumin reduction and total protein induced by adrenaline injection. SAMWA methanolic extract could protect liver and kidney of rats exposed to adrenaline.
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| first_indexed | 2024-03-08T14:36:41Z |
| format | Article |
| id | doaj.art-d7a0e12ff4e1465fbfd8df98b0027bb0 |
| institution | Directory Open Access Journal |
| issn | 2090-6269 2090-6277 |
| language | English |
| last_indexed | 2024-03-08T14:36:41Z |
| publishDate | 2024-01-01 |
| publisher | Assiut University |
| record_format | Article |
| series | Journal of Advanced Veterinary Research |
| spelling | doaj.art-d7a0e12ff4e1465fbfd8df98b0027bb02024-01-12T04:47:17ZengAssiut UniversityJournal of Advanced Veterinary Research2090-62692090-62772024-01-011310The Reno and Hepatoprotective Effects of SAMWA Plant (Cleome droserifolia) Methanolic Extract against Adrenaline-Induced Adverse Effect to Male RatsSahar A. Abou Haleka0Hanan M. Rashwan1Hala M. Ebaid2Heba N. Gad El Hak3Dima Alkadri4Heba M.A. Abdelrazek5Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt.Department of Zoology, Science Faculty, Al Arish University, North Sinai, Egypt.Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt.Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt.Department of Nutrition and Food Science, Faculty of Agriculture, Jerash University, Jerash, Jordan.Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt. Adrenaline is widely used drug to combat several conditions such as allergy and anaphylaxis. The current work was to investigate the renal and hepatic complications following adrenaline injection, in addition, the impact of Cleome (SAMWA) methanolic extract on adrenaline- induced renal and hepatic alterations. Twenty-four male Wister rats were divided equally into four groups; Normal control group received oral distilled water for 30 consecutive days and administered subcutaneous saline on the 31st and 32nd days. The Cleome extract (200 mg/kg) group received Cleome methanolic extract (200 mg/kg, P.O) for 30 consecutive days and administered subcutaneous saline on the 31st and 32nd days. The adrenaline group received distilled water orally for 30 consecutive days and administered subcutaneous adrenaline (2 mg/kg, s.c.) divided into two doses (1 mg/kg, s.c) each on the 31st and 32nd days. Cleome extract (200 mg/kg)/ adrenaline received Cleome methanolic extract (200 mg/kg, P. O) for 30 consecutive days and administered subcutaneous adrenaline (2 mg/kg, s.c.) divided into two doses (1 mg/kg, s.c) each on the 31st and 32nd days. Liver and kidney function biomarkers in addition to histopathological analyses were evaluated. Adrenaline caused alteration in liver and kidney function biomarkers without affecting the histological structure of the liver and the kidney. SAMWA methanolic extract pretreatment significantly decreased serum urea, uric acid, aspartate aminotransferase (AST), alanine transaminase (ALT) and Alkaline Phosphatase (ALP). SAMWA ameliorated serum albumin reduction and total protein induced by adrenaline injection. SAMWA methanolic extract could protect liver and kidney of rats exposed to adrenaline. https://www.advetresearch.com/index.php/AVR/article/view/1666 AdrenalineHepatic functionHistopatholgyRenal functionSAMWA |
| spellingShingle | Sahar A. Abou Haleka Hanan M. Rashwan Hala M. Ebaid Heba N. Gad El Hak Dima Alkadri Heba M.A. Abdelrazek The Reno and Hepatoprotective Effects of SAMWA Plant (Cleome droserifolia) Methanolic Extract against Adrenaline-Induced Adverse Effect to Male Rats Journal of Advanced Veterinary Research Adrenaline Hepatic function Histopatholgy Renal function SAMWA |
| title | The Reno and Hepatoprotective Effects of SAMWA Plant (Cleome droserifolia) Methanolic Extract against Adrenaline-Induced Adverse Effect to Male Rats |
| title_full | The Reno and Hepatoprotective Effects of SAMWA Plant (Cleome droserifolia) Methanolic Extract against Adrenaline-Induced Adverse Effect to Male Rats |
| title_fullStr | The Reno and Hepatoprotective Effects of SAMWA Plant (Cleome droserifolia) Methanolic Extract against Adrenaline-Induced Adverse Effect to Male Rats |
| title_full_unstemmed | The Reno and Hepatoprotective Effects of SAMWA Plant (Cleome droserifolia) Methanolic Extract against Adrenaline-Induced Adverse Effect to Male Rats |
| title_short | The Reno and Hepatoprotective Effects of SAMWA Plant (Cleome droserifolia) Methanolic Extract against Adrenaline-Induced Adverse Effect to Male Rats |
| title_sort | reno and hepatoprotective effects of samwa plant cleome droserifolia methanolic extract against adrenaline induced adverse effect to male rats |
| topic | Adrenaline Hepatic function Histopatholgy Renal function SAMWA |
| url | https://www.advetresearch.com/index.php/AVR/article/view/1666 |
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