Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR
BackgroundCardiac infiltration is the major predictor of poor prognosis in patients with systemic amyloidosis, thus it becomes of great importance to evaluate cardiac involvement.PurposeWe aimed to evaluate left ventricular myocardial deformation alteration in patients with cardiac amyloidosis (CA)...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Radiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fradi.2023.1115527/full |
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| author | Zheng Li Zheng Li Zheng Li Cheng Yan Cheng Yan Guo-Xiang Hu Guo-Xiang Hu Rui Zhao Hang Jin Hang Jin Hong Yun Hong Yun Zheng Wei Cui-Zhen Pan Cui-Zhen Pan Cui-Zhen Pan Xian-Hong Shu Xian-Hong Shu Xian-Hong Shu Meng-Su Zeng Meng-Su Zeng |
| author_facet | Zheng Li Zheng Li Zheng Li Cheng Yan Cheng Yan Guo-Xiang Hu Guo-Xiang Hu Rui Zhao Hang Jin Hang Jin Hong Yun Hong Yun Zheng Wei Cui-Zhen Pan Cui-Zhen Pan Cui-Zhen Pan Xian-Hong Shu Xian-Hong Shu Xian-Hong Shu Meng-Su Zeng Meng-Su Zeng |
| author_sort | Zheng Li |
| collection | DOAJ |
| description | BackgroundCardiac infiltration is the major predictor of poor prognosis in patients with systemic amyloidosis, thus it becomes of great importance to evaluate cardiac involvement.PurposeWe aimed to evaluate left ventricular myocardial deformation alteration in patients with cardiac amyloidosis (CA) using layer-specific tissue tracking MR.Material and MethodsThirty-nine patients with CA were enrolled. Thirty-nine normal controls were also recruited. Layer-specific tissue tracking analysis was done based on cine MR images.ResultsCompared with the control group, a significant reduction in LV whole layer strain values (GLS, GCS, and GRS) and layer-specific strain values was found in patients with CA (all P < 0.01). In addition, GRS and GLS, as well as subendocardial and subepicardial GLS, GRS, and GCS, were all diminished in patients with CA and reduced LVEF, when compared to those with preserved or mid-range LVEF (all P < 0.05). GCS showed the largest AUC (0.9952, P = 0.0001) with a sensitivity of 93.1% and specificity of 90% to predict reduced LVEF (<40%). Moreover, GCS was the only independent predictor of LV systolic dysfunction (Odds Ratio: 3.30, 95% CI:1.341–8.12, and P = 0.009).ConclusionLayer-specific tissue tracking MR could be a useful method to assess left ventricular myocardial deformation in patients with CA. |
| first_indexed | 2024-03-12T17:44:04Z |
| format | Article |
| id | doaj.art-d7a2955f4c2447628dbf143daef004fc |
| institution | Directory Open Access Journal |
| issn | 2673-8740 |
| language | English |
| last_indexed | 2024-03-12T17:44:04Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Radiology |
| spelling | doaj.art-d7a2955f4c2447628dbf143daef004fc2023-08-03T22:55:51ZengFrontiers Media S.A.Frontiers in Radiology2673-87402023-08-01310.3389/fradi.2023.11155271115527Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MRZheng Li0Zheng Li1Zheng Li2Cheng Yan3Cheng Yan4Guo-Xiang Hu5Guo-Xiang Hu6Rui Zhao7Hang Jin8Hang Jin9Hong Yun10Hong Yun11Zheng Wei12Cui-Zhen Pan13Cui-Zhen Pan14Cui-Zhen Pan15Xian-Hong Shu16Xian-Hong Shu17Xian-Hong Shu18Meng-Su Zeng19Meng-Su Zeng20Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Cardiovascular Disease, Shanghai, ChinaShanghai Institute of Medical Imaging, Shanghai, ChinaShanghai Institute of Medical Imaging, Shanghai, ChinaDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Medical Imaging, Shanghai, ChinaDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, United StatesShanghai Institute of Medical Imaging, Shanghai, ChinaDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Medical Imaging, Shanghai, ChinaDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Cardiovascular Disease, Shanghai, ChinaShanghai Institute of Medical Imaging, Shanghai, ChinaDepartment of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, ChinaShanghai Institute of Cardiovascular Disease, Shanghai, ChinaShanghai Institute of Medical Imaging, Shanghai, ChinaShanghai Institute of Medical Imaging, Shanghai, ChinaDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaBackgroundCardiac infiltration is the major predictor of poor prognosis in patients with systemic amyloidosis, thus it becomes of great importance to evaluate cardiac involvement.PurposeWe aimed to evaluate left ventricular myocardial deformation alteration in patients with cardiac amyloidosis (CA) using layer-specific tissue tracking MR.Material and MethodsThirty-nine patients with CA were enrolled. Thirty-nine normal controls were also recruited. Layer-specific tissue tracking analysis was done based on cine MR images.ResultsCompared with the control group, a significant reduction in LV whole layer strain values (GLS, GCS, and GRS) and layer-specific strain values was found in patients with CA (all P < 0.01). In addition, GRS and GLS, as well as subendocardial and subepicardial GLS, GRS, and GCS, were all diminished in patients with CA and reduced LVEF, when compared to those with preserved or mid-range LVEF (all P < 0.05). GCS showed the largest AUC (0.9952, P = 0.0001) with a sensitivity of 93.1% and specificity of 90% to predict reduced LVEF (<40%). Moreover, GCS was the only independent predictor of LV systolic dysfunction (Odds Ratio: 3.30, 95% CI:1.341–8.12, and P = 0.009).ConclusionLayer-specific tissue tracking MR could be a useful method to assess left ventricular myocardial deformation in patients with CA.https://www.frontiersin.org/articles/10.3389/fradi.2023.1115527/fullamyloidosismagnetic resonance imagingleft ventricular functionlayer specific strainlate gadolinium enhanced (LGE) |
| spellingShingle | Zheng Li Zheng Li Zheng Li Cheng Yan Cheng Yan Guo-Xiang Hu Guo-Xiang Hu Rui Zhao Hang Jin Hang Jin Hong Yun Hong Yun Zheng Wei Cui-Zhen Pan Cui-Zhen Pan Cui-Zhen Pan Xian-Hong Shu Xian-Hong Shu Xian-Hong Shu Meng-Su Zeng Meng-Su Zeng Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR Frontiers in Radiology amyloidosis magnetic resonance imaging left ventricular function layer specific strain late gadolinium enhanced (LGE) |
| title | Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR |
| title_full | Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR |
| title_fullStr | Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR |
| title_full_unstemmed | Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR |
| title_short | Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR |
| title_sort | layer specific strain in patients with cardiac amyloidosis using tissue tracking mr |
| topic | amyloidosis magnetic resonance imaging left ventricular function layer specific strain late gadolinium enhanced (LGE) |
| url | https://www.frontiersin.org/articles/10.3389/fradi.2023.1115527/full |
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