PD-1 signaling modulates interferon-γ production by Gamma Delta (γδ) T-Cells in response to leukemia

PD-1 signaling modulates interferon-γ production by Gamma Delta (γδ) T-Cells in response to leukemia

Gamma delta (γδ) T-cell based immunotherapy is a promising concept for the treatment of hematologic malignancies. Not only in vitro but also in early phase clinical trials, zoledronic acid (Zol) and interleukin-2 (IL-2) have been successfully used to activate human γδ T-cells and to induce clinical...

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Bibliographic Details
Main Authors: Timm Hoeres, Elisabeth Holzmann, Manfred Smetak, Josef Birkmann, Martin Wilhelm
Format: Article
Language:English
Published: Taylor & Francis Group 2019-03-01
Series:OncoImmunology
Subjects:
pd-1
leukemia
gamma delta
t-cell
aml
zoledronic acid
il-2
pembrolizumab
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1550618

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