A Convenient Synthesis of 3,7′-Bisindole Derivatives
An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/5/638 |
| _version_ | 1819046765622460416 |
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| author | Teng Liu Hong-You Zhu Da-Yun Luo Sheng-Jiao Yan Jun Lin |
| author_facet | Teng Liu Hong-You Zhu Da-Yun Luo Sheng-Jiao Yan Jun Lin |
| author_sort | Teng Liu |
| collection | DOAJ |
| description | An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7′-bisindole derivatives in moderate to good yields. |
| first_indexed | 2024-12-21T10:49:40Z |
| format | Article |
| id | doaj.art-d7a68dc5e5a640bdb3afea49b4f27a9d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T10:49:40Z |
| publishDate | 2016-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d7a68dc5e5a640bdb3afea49b4f27a9d2022-12-21T19:06:42ZengMDPI AGMolecules1420-30492016-05-0121563810.3390/molecules21050638molecules21050638A Convenient Synthesis of 3,7′-Bisindole DerivativesTeng Liu0Hong-You Zhu1Da-Yun Luo2Sheng-Jiao Yan3Jun Lin4Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, ChinaGuangdong Goodscend Pharm. Sci &Tech. Co., Ltd., Shantou 650091, ChinaKey Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, ChinaKey Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, ChinaKey Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, ChinaAn efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7′-bisindole derivatives in moderate to good yields.http://www.mdpi.com/1420-3049/21/5/6383,7′-bisindolesMichael additioncondensation reactionheterocyclic ketene aminals |
| spellingShingle | Teng Liu Hong-You Zhu Da-Yun Luo Sheng-Jiao Yan Jun Lin A Convenient Synthesis of 3,7′-Bisindole Derivatives Molecules 3,7′-bisindoles Michael addition condensation reaction heterocyclic ketene aminals |
| title | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_full | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_fullStr | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_full_unstemmed | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_short | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_sort | convenient synthesis of 3 7 bisindole derivatives |
| topic | 3,7′-bisindoles Michael addition condensation reaction heterocyclic ketene aminals |
| url | http://www.mdpi.com/1420-3049/21/5/638 |
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