The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning
Evidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that surround neurons—in the brain, and it appears...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/13/3/200 |
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| author | Bernard G. Schreurs Deidre E. O’Dell Desheng Wang |
| author_facet | Bernard G. Schreurs Deidre E. O’Dell Desheng Wang |
| author_sort | Bernard G. Schreurs |
| collection | DOAJ |
| description | Evidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that surround neurons—in the brain, and it appears there may be a connection between these nets and cognitive processes, particularly learning and memory. Here, we review how the cerebellum is involved in eyeblink conditioning—a particularly well-understood form of learning and memory—and focus on the role of perineuronal nets in intrinsic membrane excitability and synaptic plasticity that underlie eyeblink conditioning. We explore the development and role of perineuronal nets and the in vivo and in vitro evidence that manipulations of the perineuronal net in the deep cerebellar nuclei affect eyeblink conditioning. Together, these findings provide evidence of an important role for perineuronal net in learning and memory. |
| first_indexed | 2024-04-24T18:32:45Z |
| format | Article |
| id | doaj.art-d7a6c3814cf84c76a01bbc1fe57eecdb |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-04-24T18:32:45Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-d7a6c3814cf84c76a01bbc1fe57eecdb2024-03-27T13:22:17ZengMDPI AGBiology2079-77372024-03-0113320010.3390/biology13030200The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink ConditioningBernard G. Schreurs0Deidre E. O’Dell1Desheng Wang2Department of Neuroscience, West Virginia University, Morgantown, WV 26505, USADepartment of Biology, Earth and Environmental Sciences, Pennsylvania Western (PennWest) University, California, PA 15419, USADepartment of Neuroscience, West Virginia University, Morgantown, WV 26505, USAEvidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that surround neurons—in the brain, and it appears there may be a connection between these nets and cognitive processes, particularly learning and memory. Here, we review how the cerebellum is involved in eyeblink conditioning—a particularly well-understood form of learning and memory—and focus on the role of perineuronal nets in intrinsic membrane excitability and synaptic plasticity that underlie eyeblink conditioning. We explore the development and role of perineuronal nets and the in vivo and in vitro evidence that manipulations of the perineuronal net in the deep cerebellar nuclei affect eyeblink conditioning. Together, these findings provide evidence of an important role for perineuronal net in learning and memory.https://www.mdpi.com/2079-7737/13/3/200cerebellumclassical conditioningintrinsic membrane excitabilityperineuronal netssynaptic plasticity |
| spellingShingle | Bernard G. Schreurs Deidre E. O’Dell Desheng Wang The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning Biology cerebellum classical conditioning intrinsic membrane excitability perineuronal nets synaptic plasticity |
| title | The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning |
| title_full | The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning |
| title_fullStr | The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning |
| title_full_unstemmed | The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning |
| title_short | The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning |
| title_sort | role of cerebellar intrinsic neuronal excitability synaptic plasticity and perineuronal nets in eyeblink conditioning |
| topic | cerebellum classical conditioning intrinsic membrane excitability perineuronal nets synaptic plasticity |
| url | https://www.mdpi.com/2079-7737/13/3/200 |
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