Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity
Various immune cells are involved in host tumor immune responses. In particular, there are many T cell subsets with different roles in tumor immunity. T-helper (Th) 1 cells are involved in cellular immunity and thus play the major role in host anti-tumor immunity by inducing and activating cytotoxic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/23/6132 |
| _version_ | 1797507951018115072 |
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| author | Kazuhiko Matsuo Osamu Yoshie Takashi Nakayama |
| author_facet | Kazuhiko Matsuo Osamu Yoshie Takashi Nakayama |
| author_sort | Kazuhiko Matsuo |
| collection | DOAJ |
| description | Various immune cells are involved in host tumor immune responses. In particular, there are many T cell subsets with different roles in tumor immunity. T-helper (Th) 1 cells are involved in cellular immunity and thus play the major role in host anti-tumor immunity by inducing and activating cytotoxic T lymphocytes (CTLs). On the other hand, Th2 cells are involved in humoral immunity and suppressive to Th1 responses. Regulatory T (Treg) cells negatively regulate immune responses and contribute to immune evasion of tumor cells. Th17 cells are involved in inflammatory responses and may play a role in tumor progression. However, recent studies have also shown that Th17 cells are capable of directly inducting CTLs and thus may promote anti-tumor immunity. Besides these T cell subsets, there are many other innate immune cells such as dendritic cells (DCs), natural killer (NK) cells, and myeloid-derived suppressor cells (MDSCs) that are involved in host immune responses to cancer. The migratory properties of various immune cells are critical for their functions and largely regulated by the chemokine superfamily. Thus, chemokines and chemokine receptors play vital roles in the orchestration of host immune responses to cancer. In this review, we overview the various immune cells involved in host responses to cancer and their migratory properties regulated by the chemokine superfamily. Understanding the roles of chemokines and chemokine receptors in host immune responses to cancer may provide new therapeutic opportunities for cancer immunotherapy. |
| first_indexed | 2024-03-10T04:55:42Z |
| format | Article |
| id | doaj.art-d7a6d71613104cebad1770856d708b37 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:55:42Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d7a6d71613104cebad1770856d708b372023-11-23T02:15:12ZengMDPI AGCancers2072-66942021-12-011323613210.3390/cancers13236132Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor ImmunityKazuhiko Matsuo0Osamu Yoshie1Takashi Nakayama2Division of Chemotherapy, Faculty of Pharmacy, Kindai University, Osaka 577-8502, JapanHealth and Kampo Institute, Murasakiyama, Izumi, Sendai 981-3205, JapanDivision of Chemotherapy, Faculty of Pharmacy, Kindai University, Osaka 577-8502, JapanVarious immune cells are involved in host tumor immune responses. In particular, there are many T cell subsets with different roles in tumor immunity. T-helper (Th) 1 cells are involved in cellular immunity and thus play the major role in host anti-tumor immunity by inducing and activating cytotoxic T lymphocytes (CTLs). On the other hand, Th2 cells are involved in humoral immunity and suppressive to Th1 responses. Regulatory T (Treg) cells negatively regulate immune responses and contribute to immune evasion of tumor cells. Th17 cells are involved in inflammatory responses and may play a role in tumor progression. However, recent studies have also shown that Th17 cells are capable of directly inducting CTLs and thus may promote anti-tumor immunity. Besides these T cell subsets, there are many other innate immune cells such as dendritic cells (DCs), natural killer (NK) cells, and myeloid-derived suppressor cells (MDSCs) that are involved in host immune responses to cancer. The migratory properties of various immune cells are critical for their functions and largely regulated by the chemokine superfamily. Thus, chemokines and chemokine receptors play vital roles in the orchestration of host immune responses to cancer. In this review, we overview the various immune cells involved in host responses to cancer and their migratory properties regulated by the chemokine superfamily. Understanding the roles of chemokines and chemokine receptors in host immune responses to cancer may provide new therapeutic opportunities for cancer immunotherapy.https://www.mdpi.com/2072-6694/13/23/6132chemokinechemokine receptorTh1Th2Th17regulatory T |
| spellingShingle | Kazuhiko Matsuo Osamu Yoshie Takashi Nakayama Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity Cancers chemokine chemokine receptor Th1 Th2 Th17 regulatory T |
| title | Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity |
| title_full | Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity |
| title_fullStr | Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity |
| title_full_unstemmed | Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity |
| title_short | Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity |
| title_sort | multifaceted roles of chemokines and chemokine receptors in tumor immunity |
| topic | chemokine chemokine receptor Th1 Th2 Th17 regulatory T |
| url | https://www.mdpi.com/2072-6694/13/23/6132 |
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