Lead exposure was associated with liver fibrosis in subjects without known chronic liver disease: An analysis of NHANES 2017–2020
Lead is one of the most important toxic heavy metals in the environment; however, the relationship between blood lead levels and liver fibrosis in individuals without chronic liver diseases (CLD) is unclear. This study used data obtained from the National Health and Nutrition Examination Survey (NHA...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Environmental Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fenvs.2022.995795/full |
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| author | Zhiqiang Zhang Zhiqiang Zhang Zhangping Li Haiyan Lin Haiyan Lin Zhiyu Zeng Zhiyu Zeng Jiaofeng Huang Dongliang Li Dongliang Li |
| author_facet | Zhiqiang Zhang Zhiqiang Zhang Zhangping Li Haiyan Lin Haiyan Lin Zhiyu Zeng Zhiyu Zeng Jiaofeng Huang Dongliang Li Dongliang Li |
| author_sort | Zhiqiang Zhang |
| collection | DOAJ |
| description | Lead is one of the most important toxic heavy metals in the environment; however, the relationship between blood lead levels and liver fibrosis in individuals without chronic liver diseases (CLD) is unclear. This study used data obtained from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. Multivariate logistic regression was used to explore the relationship between the blood lead level and significant liver fibrosis. A total of 1962 cases without underlying CLD were included, 77 (3.9%) of whom were diagnosed with advanced liver fibrosis by transient elastography. The proportion of advanced fibrosis significantly increased with the blood lead level (p < 0.001), and the blood lead level was higher in the fibrosis group than in the non-fibrosis group (1.2 μg/dl vs 0.9 μg/dl, p < 0.001). After adjusting for relevant confounding factors, the blood lead level was found to be independently associated with advanced liver fibrosis (OR = 1.168; 95% CI, 1.006–1.356; p = 0.041). The blood lead level remained an independent risk factor for advanced liver fibrosis (OR = 1.249; 95% CI, 1.048–1.489; p = 0.013) after controlling for age and sex through propensity score matching. In conclusion, the blood lead level is associated with liver fibrosis in individuals without known CLD. |
| first_indexed | 2024-04-13T23:36:38Z |
| format | Article |
| id | doaj.art-d7a7f7464581427b9038c496b2d0515f |
| institution | Directory Open Access Journal |
| issn | 2296-665X |
| language | English |
| last_indexed | 2024-04-13T23:36:38Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Environmental Science |
| spelling | doaj.art-d7a7f7464581427b9038c496b2d0515f2022-12-22T02:24:44ZengFrontiers Media S.A.Frontiers in Environmental Science2296-665X2022-10-011010.3389/fenvs.2022.995795995795Lead exposure was associated with liver fibrosis in subjects without known chronic liver disease: An analysis of NHANES 2017–2020Zhiqiang Zhang0Zhiqiang Zhang1Zhangping Li2Haiyan Lin3Haiyan Lin4Zhiyu Zeng5Zhiyu Zeng6Jiaofeng Huang7Dongliang Li8Dongliang Li9Department of Hepatobiliary Disease, The 900th Hospital of Joint Logistics Support Force, Fuzhou, ChinaDepartment of Hepatobiliary Disease, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Hepatobiliary Disease, Cangshan District of the 900th Hospital of Joint Logistics Support Force, Fuzhou, ChinaDepartment of Hepatobiliary Disease, The 900th Hospital of Joint Logistics Support Force, Fuzhou, ChinaDepartment of Hepatobiliary Disease, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Hepatobiliary Disease, The 900th Hospital of Joint Logistics Support Force, Fuzhou, ChinaDepartment of Hepatobiliary Disease, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Hepatobiliary Disease, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Hepatobiliary Disease, The 900th Hospital of Joint Logistics Support Force, Fuzhou, ChinaDepartment of Hepatobiliary Disease, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaLead is one of the most important toxic heavy metals in the environment; however, the relationship between blood lead levels and liver fibrosis in individuals without chronic liver diseases (CLD) is unclear. This study used data obtained from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. Multivariate logistic regression was used to explore the relationship between the blood lead level and significant liver fibrosis. A total of 1962 cases without underlying CLD were included, 77 (3.9%) of whom were diagnosed with advanced liver fibrosis by transient elastography. The proportion of advanced fibrosis significantly increased with the blood lead level (p < 0.001), and the blood lead level was higher in the fibrosis group than in the non-fibrosis group (1.2 μg/dl vs 0.9 μg/dl, p < 0.001). After adjusting for relevant confounding factors, the blood lead level was found to be independently associated with advanced liver fibrosis (OR = 1.168; 95% CI, 1.006–1.356; p = 0.041). The blood lead level remained an independent risk factor for advanced liver fibrosis (OR = 1.249; 95% CI, 1.048–1.489; p = 0.013) after controlling for age and sex through propensity score matching. In conclusion, the blood lead level is associated with liver fibrosis in individuals without known CLD.https://www.frontiersin.org/articles/10.3389/fenvs.2022.995795/fullleadfibrosisenvironmentliverNHANES |
| spellingShingle | Zhiqiang Zhang Zhiqiang Zhang Zhangping Li Haiyan Lin Haiyan Lin Zhiyu Zeng Zhiyu Zeng Jiaofeng Huang Dongliang Li Dongliang Li Lead exposure was associated with liver fibrosis in subjects without known chronic liver disease: An analysis of NHANES 2017–2020 Frontiers in Environmental Science lead fibrosis environment liver NHANES |
| title | Lead exposure was associated with liver fibrosis in subjects without known chronic liver disease: An analysis of NHANES 2017–2020 |
| title_full | Lead exposure was associated with liver fibrosis in subjects without known chronic liver disease: An analysis of NHANES 2017–2020 |
| title_fullStr | Lead exposure was associated with liver fibrosis in subjects without known chronic liver disease: An analysis of NHANES 2017–2020 |
| title_full_unstemmed | Lead exposure was associated with liver fibrosis in subjects without known chronic liver disease: An analysis of NHANES 2017–2020 |
| title_short | Lead exposure was associated with liver fibrosis in subjects without known chronic liver disease: An analysis of NHANES 2017–2020 |
| title_sort | lead exposure was associated with liver fibrosis in subjects without known chronic liver disease an analysis of nhanes 2017 2020 |
| topic | lead fibrosis environment liver NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fenvs.2022.995795/full |
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