Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening
Background and study aims Of the participants in the Danish screening program, 89.9 % to 92.5 % have fecal immunochemical test (FIT) values < 10 μg/g feces (equivalent to 50 ng hemoglobin/mL buffer). This study aimed to investigate the risk of interval colorectal cancer (CRC) in this group before...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Georg Thieme Verlag KG
2022-04-01
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| Series: | Endoscopy International Open |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1743-2651 |
| _version_ | 1818250838968107008 |
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| author | Eva Plantener Ulrik Deding Jeppe Buur Madsen Rasmus Kroijer Jonna Skov Madsen Gunnar Baatrup |
| author_facet | Eva Plantener Ulrik Deding Jeppe Buur Madsen Rasmus Kroijer Jonna Skov Madsen Gunnar Baatrup |
| author_sort | Eva Plantener |
| collection | DOAJ |
| description | Background and study aims Of the participants in the Danish screening program, 89.9 % to 92.5 % have fecal immunochemical test (FIT) values < 10 μg/g feces (equivalent to 50 ng hemoglobin/mL buffer). This study aimed to investigate the risk of interval colorectal cancer (CRC) in this group before the next biennial screening round.
Patients and methods This cohort study included all citizens from the region of Southern Denmark who participated in the Danish bowel screening program from 2014 trough 2016 and had a FIT value < 10 μg/g feces. Individuals receiving a CRC diagnosis were identified through the national CRC registry, with a follow up of 2 years corresponding to the current screening interval. We also examined the 3-year CRC incidence. Hazard ratios (HRs) were estimated using univariate and multivariate Cox proportional hazard regression models.
Results Data from 185,654 citizens presenting with a FIT value < 10 μg/g feces were eligible for analysis. Overall, interval CRC incidence was 0.07 % within 2 years with HRs of 4.16 (95 % confidence interval [CI] 2.67;6.48) and 5.8 (95 % CI 3.34;10.05) for FIT values of 4 to 6.9 μg/g feces and 7 to 9.9 μg/g feces, respectively, compared to those having a FIT value below the limit of quantification of 4 μg/g feces. After 3 years, the overall CRC incidence increased to 0.14 %; however, this was not significant.
Conclusions This study demonstrates a positive correlation between FIT value and risk of interval cancer even for very low values. It further suggests that an increase in the screening interval could be reasonable in the low FIT categories. |
| first_indexed | 2024-12-12T15:58:45Z |
| format | Article |
| id | doaj.art-d7a895417bf745bcb025e5eca0e998e7 |
| institution | Directory Open Access Journal |
| issn | 2364-3722 2196-9736 |
| language | English |
| last_indexed | 2024-12-12T15:58:45Z |
| publishDate | 2022-04-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Endoscopy International Open |
| spelling | doaj.art-d7a895417bf745bcb025e5eca0e998e72022-12-22T00:19:26ZengGeorg Thieme Verlag KGEndoscopy International Open2364-37222196-97362022-04-011004E413E41910.1055/a-1743-2651Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screeningEva Plantener0Ulrik Deding1Jeppe Buur Madsen2Rasmus Kroijer3Jonna Skov Madsen4Gunnar Baatrup5Odense University Hospital, Department of Surgery, Svendborg, DenmarkOdense University Hospital, Department of Surgery, Svendborg, DenmarkUniversity Hospital Lillebaelt, Department of Biochemistry and Immunology, Vejle, DenmarkHospital South West Jutland, Department of Surgery, Esbjerg, DenmarkUniversity Hospital Lillebaelt, Department of Biochemistry and Immunology, Vejle, DenmarkOdense University Hospital, Department of Surgery, Svendborg, DenmarkBackground and study aims Of the participants in the Danish screening program, 89.9 % to 92.5 % have fecal immunochemical test (FIT) values < 10 μg/g feces (equivalent to 50 ng hemoglobin/mL buffer). This study aimed to investigate the risk of interval colorectal cancer (CRC) in this group before the next biennial screening round. Patients and methods This cohort study included all citizens from the region of Southern Denmark who participated in the Danish bowel screening program from 2014 trough 2016 and had a FIT value < 10 μg/g feces. Individuals receiving a CRC diagnosis were identified through the national CRC registry, with a follow up of 2 years corresponding to the current screening interval. We also examined the 3-year CRC incidence. Hazard ratios (HRs) were estimated using univariate and multivariate Cox proportional hazard regression models. Results Data from 185,654 citizens presenting with a FIT value < 10 μg/g feces were eligible for analysis. Overall, interval CRC incidence was 0.07 % within 2 years with HRs of 4.16 (95 % confidence interval [CI] 2.67;6.48) and 5.8 (95 % CI 3.34;10.05) for FIT values of 4 to 6.9 μg/g feces and 7 to 9.9 μg/g feces, respectively, compared to those having a FIT value below the limit of quantification of 4 μg/g feces. After 3 years, the overall CRC incidence increased to 0.14 %; however, this was not significant. Conclusions This study demonstrates a positive correlation between FIT value and risk of interval cancer even for very low values. It further suggests that an increase in the screening interval could be reasonable in the low FIT categories.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1743-2651 |
| spellingShingle | Eva Plantener Ulrik Deding Jeppe Buur Madsen Rasmus Kroijer Jonna Skov Madsen Gunnar Baatrup Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening Endoscopy International Open |
| title | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
| title_full | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
| title_fullStr | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
| title_full_unstemmed | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
| title_short | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
| title_sort | using fecal immunochemical test values below conventional cut off to individualize colorectal cancer screening |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1743-2651 |
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