In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
Rotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10236-7 |
| _version_ | 1818851002708656128 |
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| author | Ke Ding Cristina C. Celma Xing Zhang Thomas Chang Wesley Shen Ivo Atanasov Polly Roy Z. Hong Zhou |
| author_facet | Ke Ding Cristina C. Celma Xing Zhang Thomas Chang Wesley Shen Ivo Atanasov Polly Roy Z. Hong Zhou |
| author_sort | Ke Ding |
| collection | DOAJ |
| description | Rotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for antiviral drug design. |
| first_indexed | 2024-12-19T06:58:06Z |
| format | Article |
| id | doaj.art-d7ab0cfbd1d642369d08a8a85f7cd652 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T06:58:06Z |
| publishDate | 2019-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d7ab0cfbd1d642369d08a8a85f7cd6522022-12-21T20:31:29ZengNature PortfolioNature Communications2041-17232019-05-011011910.1038/s41467-019-10236-7In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and releaseKe Ding0Cristina C. Celma1Xing Zhang2Thomas Chang3Wesley Shen4Ivo Atanasov5Polly Roy6Z. Hong Zhou7Department of Bioengineering, University of CaliforniaDepartment of Pathogen Molecular Biology, London School of Hygiene and Tropical MedicineCalifornia NanoSystems Institute, University of CaliforniaCalifornia NanoSystems Institute, University of CaliforniaCalifornia NanoSystems Institute, University of CaliforniaCalifornia NanoSystems Institute, University of CaliforniaDepartment of Pathogen Molecular Biology, London School of Hygiene and Tropical MedicineDepartment of Bioengineering, University of CaliforniaRotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for antiviral drug design.https://doi.org/10.1038/s41467-019-10236-7 |
| spellingShingle | Ke Ding Cristina C. Celma Xing Zhang Thomas Chang Wesley Shen Ivo Atanasov Polly Roy Z. Hong Zhou In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release Nature Communications |
| title | In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
| title_full | In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
| title_fullStr | In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
| title_full_unstemmed | In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
| title_short | In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
| title_sort | in situ structures of rotavirus polymerase in action and mechanism of mrna transcription and release |
| url | https://doi.org/10.1038/s41467-019-10236-7 |
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