Targeting Mitochondria to Control Ageing and Senescence
Ageing is accompanied by a progressive impairment of cellular function and a systemic deterioration of tissues and organs, resulting in increased vulnerability to multiple diseases. Here, we review the interplay between two hallmarks of ageing, namely, mitochondrial dysfunction and cellular senescen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/2/352 |
| _version_ | 1827756026631290880 |
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| author | Margherita Protasoni Manuel Serrano |
| author_facet | Margherita Protasoni Manuel Serrano |
| author_sort | Margherita Protasoni |
| collection | DOAJ |
| description | Ageing is accompanied by a progressive impairment of cellular function and a systemic deterioration of tissues and organs, resulting in increased vulnerability to multiple diseases. Here, we review the interplay between two hallmarks of ageing, namely, mitochondrial dysfunction and cellular senescence. The targeting of specific mitochondrial features in senescent cells has the potential of delaying or even reverting the ageing process. A deeper and more comprehensive understanding of mitochondrial biology in senescent cells is necessary to effectively face this challenge. Here, we discuss the main alterations in mitochondrial functions and structure in both ageing and cellular senescence, highlighting the differences and similarities between the two processes. Moreover, we describe the treatments available to target these pathways and speculate on possible future directions of anti-ageing and anti-senescence therapies targeting mitochondria. |
| first_indexed | 2024-03-11T08:18:22Z |
| format | Article |
| id | doaj.art-d7ace0c289464746bf058e9eb069f807 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T08:18:22Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d7ace0c289464746bf058e9eb069f8072023-11-16T22:38:46ZengMDPI AGPharmaceutics1999-49232023-01-0115235210.3390/pharmaceutics15020352Targeting Mitochondria to Control Ageing and SenescenceMargherita Protasoni0Manuel Serrano1Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, SpainInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, SpainAgeing is accompanied by a progressive impairment of cellular function and a systemic deterioration of tissues and organs, resulting in increased vulnerability to multiple diseases. Here, we review the interplay between two hallmarks of ageing, namely, mitochondrial dysfunction and cellular senescence. The targeting of specific mitochondrial features in senescent cells has the potential of delaying or even reverting the ageing process. A deeper and more comprehensive understanding of mitochondrial biology in senescent cells is necessary to effectively face this challenge. Here, we discuss the main alterations in mitochondrial functions and structure in both ageing and cellular senescence, highlighting the differences and similarities between the two processes. Moreover, we describe the treatments available to target these pathways and speculate on possible future directions of anti-ageing and anti-senescence therapies targeting mitochondria.https://www.mdpi.com/1999-4923/15/2/352ageingcellular senescencemitochondrial targetingnovel therapeutic approaches |
| spellingShingle | Margherita Protasoni Manuel Serrano Targeting Mitochondria to Control Ageing and Senescence Pharmaceutics ageing cellular senescence mitochondrial targeting novel therapeutic approaches |
| title | Targeting Mitochondria to Control Ageing and Senescence |
| title_full | Targeting Mitochondria to Control Ageing and Senescence |
| title_fullStr | Targeting Mitochondria to Control Ageing and Senescence |
| title_full_unstemmed | Targeting Mitochondria to Control Ageing and Senescence |
| title_short | Targeting Mitochondria to Control Ageing and Senescence |
| title_sort | targeting mitochondria to control ageing and senescence |
| topic | ageing cellular senescence mitochondrial targeting novel therapeutic approaches |
| url | https://www.mdpi.com/1999-4923/15/2/352 |
| work_keys_str_mv | AT margheritaprotasoni targetingmitochondriatocontrolageingandsenescence AT manuelserrano targetingmitochondriatocontrolageingandsenescence |