Research priorities for therapeutic plasma exchange in critically ill patients
Abstract Therapeutic plasma exchange (TPE) is a therapeutic intervention that separates plasma from blood cells to remove pathological factors or to replenish deficient factors. The use of TPE is increasing over the last decades. However, despite a good theoretical rationale and biological plausibil...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-05-01
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| Series: | Intensive Care Medicine Experimental |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40635-023-00510-w |
| _version_ | 1797827739387953152 |
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| author | Sascha David Lene Russell Pedro Castro Andry van de Louw Lara Zafrani Tasneem Pirani Nathan D. Nielsen Eric Mariotte Bruno L. Ferreyro Jan T. Kielstein Luca Montini Anne C. Brignier Matthias Kochanek Joan Cid Chiara Robba Ignacio Martin-Loeches Marlies Ostermann Nicole P. Juffermans for the Nine-I investigators |
| author_facet | Sascha David Lene Russell Pedro Castro Andry van de Louw Lara Zafrani Tasneem Pirani Nathan D. Nielsen Eric Mariotte Bruno L. Ferreyro Jan T. Kielstein Luca Montini Anne C. Brignier Matthias Kochanek Joan Cid Chiara Robba Ignacio Martin-Loeches Marlies Ostermann Nicole P. Juffermans for the Nine-I investigators |
| author_sort | Sascha David |
| collection | DOAJ |
| description | Abstract Therapeutic plasma exchange (TPE) is a therapeutic intervention that separates plasma from blood cells to remove pathological factors or to replenish deficient factors. The use of TPE is increasing over the last decades. However, despite a good theoretical rationale and biological plausibility for TPE as a therapy for numerous diseases or syndromes associated with critical illness, TPE in the intensive care unit (ICU) setting has not been studied extensively. A group of eighteen experts around the globe from different clinical backgrounds used a modified Delphi method to phrase key research questions related to “TPE in the critically ill patient”. These questions focused on: (1) the pathophysiological role of the removal and replacement process, (2) optimal timing of treatment, (3) dosing and treatment regimes, (4) risk–benefit assumptions and (5) novel indications in need of exploration. For all five topics, the current understanding as well as gaps in knowledge and future directions were assessed. The content should stimulate future research in the field and novel clinical applications. |
| first_indexed | 2024-04-09T12:53:12Z |
| format | Article |
| id | doaj.art-d7ad31a008e04961936cf47fa872aa5c |
| institution | Directory Open Access Journal |
| issn | 2197-425X |
| language | English |
| last_indexed | 2024-04-09T12:53:12Z |
| publishDate | 2023-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Intensive Care Medicine Experimental |
| spelling | doaj.art-d7ad31a008e04961936cf47fa872aa5c2023-05-14T11:05:53ZengSpringerOpenIntensive Care Medicine Experimental2197-425X2023-05-0111112010.1186/s40635-023-00510-wResearch priorities for therapeutic plasma exchange in critically ill patientsSascha David0Lene Russell1Pedro Castro2Andry van de Louw3Lara Zafrani4Tasneem Pirani5Nathan D. Nielsen6Eric Mariotte7Bruno L. Ferreyro8Jan T. Kielstein9Luca Montini10Anne C. Brignier11Matthias Kochanek12Joan Cid13Chiara Robba14Ignacio Martin-Loeches15Marlies Ostermann16Nicole P. Juffermans17for the Nine-I investigatorsInstitute of Intensive Care Medicine, University Hospital ZurichDepartment of Intensive Care, Copenhagen University Hospital GentofteMedical Intensive Care Unit, Hospital Clínic of Barcelona, IDIBAPS, University of BarcelonaMedical Intensive Care Unit, Penn State Health Hershey Medical CenterMedical Intensive Care Unit, Saint-Louis Hospital, AP-HP, University of Paris CitéKing’s College Hospital, General and Liver Intensive CareDivision of Pulmonary, Critical Care and Sleep Medicine & Section of Transfusion Medicine and Therapeutic Pathology, University of New Mexico School of MedicineMedical Intensive Care Unit, Saint-Louis Hospital, AP-HP, University of Paris CitéDepartment of Medicine, Sinai Health System and University Health NetworkMedical Clinic V, Nephrology, Rheumatology, Blood Purification, Academic Teaching Hospital BraunschweigDepartment of Intensive Care Medicine and Anesthesiology, “Fondazione Policlinico Universitario Agostino Gemelli IRCCS” Università Cattolica del Sacro CuoreApheresis Unit, Saint-Louis Hospital, AP-HP, University of Paris CiteDepartment I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO), University of CologneApheresis and Cellular Therapy Unit, Department of Hemotherapy and Hemostasis, ICMHO, Clínic Barcelona, IDIBAPS, University of BarcelonaIRCCS per Oncologia e NeuroscienzeDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James’s HospitalDepartment of Intensive Care, Guy’s & St Thomas’ Hospital, King’s College LondonDepartment of Intensive Care, OLVG HospitalAbstract Therapeutic plasma exchange (TPE) is a therapeutic intervention that separates plasma from blood cells to remove pathological factors or to replenish deficient factors. The use of TPE is increasing over the last decades. However, despite a good theoretical rationale and biological plausibility for TPE as a therapy for numerous diseases or syndromes associated with critical illness, TPE in the intensive care unit (ICU) setting has not been studied extensively. A group of eighteen experts around the globe from different clinical backgrounds used a modified Delphi method to phrase key research questions related to “TPE in the critically ill patient”. These questions focused on: (1) the pathophysiological role of the removal and replacement process, (2) optimal timing of treatment, (3) dosing and treatment regimes, (4) risk–benefit assumptions and (5) novel indications in need of exploration. For all five topics, the current understanding as well as gaps in knowledge and future directions were assessed. The content should stimulate future research in the field and novel clinical applications.https://doi.org/10.1186/s40635-023-00510-wKnowledgeGapsPlasmapheresisExpert panelApheresisResearch |
| spellingShingle | Sascha David Lene Russell Pedro Castro Andry van de Louw Lara Zafrani Tasneem Pirani Nathan D. Nielsen Eric Mariotte Bruno L. Ferreyro Jan T. Kielstein Luca Montini Anne C. Brignier Matthias Kochanek Joan Cid Chiara Robba Ignacio Martin-Loeches Marlies Ostermann Nicole P. Juffermans for the Nine-I investigators Research priorities for therapeutic plasma exchange in critically ill patients Intensive Care Medicine Experimental Knowledge Gaps Plasmapheresis Expert panel Apheresis Research |
| title | Research priorities for therapeutic plasma exchange in critically ill patients |
| title_full | Research priorities for therapeutic plasma exchange in critically ill patients |
| title_fullStr | Research priorities for therapeutic plasma exchange in critically ill patients |
| title_full_unstemmed | Research priorities for therapeutic plasma exchange in critically ill patients |
| title_short | Research priorities for therapeutic plasma exchange in critically ill patients |
| title_sort | research priorities for therapeutic plasma exchange in critically ill patients |
| topic | Knowledge Gaps Plasmapheresis Expert panel Apheresis Research |
| url | https://doi.org/10.1186/s40635-023-00510-w |
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