Protocol for the development of a core outcome set for neonatal sepsis (NESCOS).
Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatmen...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0295325 |
| _version_ | 1797377797020188672 |
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| author | Petek Eylul Taneri Jamie J Kirkham Eleanor J Molloy Linda Biesty Richard A Polin James L Wynn Barbara J Stoll Niranjan Kissoon Kondwani Kawaza Mandy Daly Aoife Branagan Lívia Nagy Bonnard Eric Giannoni Tobias Strunk Magdalena Ohaja Kenneth Mugabe Denise Suguitani Fiona Quirke Declan Devane |
| author_facet | Petek Eylul Taneri Jamie J Kirkham Eleanor J Molloy Linda Biesty Richard A Polin James L Wynn Barbara J Stoll Niranjan Kissoon Kondwani Kawaza Mandy Daly Aoife Branagan Lívia Nagy Bonnard Eric Giannoni Tobias Strunk Magdalena Ohaja Kenneth Mugabe Denise Suguitani Fiona Quirke Declan Devane |
| author_sort | Petek Eylul Taneri |
| collection | DOAJ |
| description | Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients' parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste. |
| first_indexed | 2024-03-08T19:57:34Z |
| format | Article |
| id | doaj.art-d7adef3b582741aca32a36188b4b3c3e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-08T19:57:34Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d7adef3b582741aca32a36188b4b3c3e2023-12-24T05:33:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011812e029532510.1371/journal.pone.0295325Protocol for the development of a core outcome set for neonatal sepsis (NESCOS).Petek Eylul TaneriJamie J KirkhamEleanor J MolloyLinda BiestyRichard A PolinJames L WynnBarbara J StollNiranjan KissoonKondwani KawazaMandy DalyAoife BranaganLívia Nagy BonnardEric GiannoniTobias StrunkMagdalena OhajaKenneth MugabeDenise SuguitaniFiona QuirkeDeclan DevaneNeonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients' parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste.https://doi.org/10.1371/journal.pone.0295325 |
| spellingShingle | Petek Eylul Taneri Jamie J Kirkham Eleanor J Molloy Linda Biesty Richard A Polin James L Wynn Barbara J Stoll Niranjan Kissoon Kondwani Kawaza Mandy Daly Aoife Branagan Lívia Nagy Bonnard Eric Giannoni Tobias Strunk Magdalena Ohaja Kenneth Mugabe Denise Suguitani Fiona Quirke Declan Devane Protocol for the development of a core outcome set for neonatal sepsis (NESCOS). PLoS ONE |
| title | Protocol for the development of a core outcome set for neonatal sepsis (NESCOS). |
| title_full | Protocol for the development of a core outcome set for neonatal sepsis (NESCOS). |
| title_fullStr | Protocol for the development of a core outcome set for neonatal sepsis (NESCOS). |
| title_full_unstemmed | Protocol for the development of a core outcome set for neonatal sepsis (NESCOS). |
| title_short | Protocol for the development of a core outcome set for neonatal sepsis (NESCOS). |
| title_sort | protocol for the development of a core outcome set for neonatal sepsis nescos |
| url | https://doi.org/10.1371/journal.pone.0295325 |
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