Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha
Retinol is widely used in topical skincare products to ameliorate skin aging and treat acne and wrinkles; however, retinol and its derivatives occasionally have adverse side effects, including the induction of irritant contact dermatitis. Previously, we reported that mead acid (5,8,11-eicosatrienoic...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1097955/full |
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| author | Azusa Saika Prabha Tiwari Prabha Tiwari Takahiro Nagatake Takahiro Nagatake Eri Node Koji Hosomi Tetsuya Honda Kenji Kabashima Jun Kunisawa Jun Kunisawa Jun Kunisawa Jun Kunisawa Jun Kunisawa Jun Kunisawa |
| author_facet | Azusa Saika Prabha Tiwari Prabha Tiwari Takahiro Nagatake Takahiro Nagatake Eri Node Koji Hosomi Tetsuya Honda Kenji Kabashima Jun Kunisawa Jun Kunisawa Jun Kunisawa Jun Kunisawa Jun Kunisawa Jun Kunisawa |
| author_sort | Azusa Saika |
| collection | DOAJ |
| description | Retinol is widely used in topical skincare products to ameliorate skin aging and treat acne and wrinkles; however, retinol and its derivatives occasionally have adverse side effects, including the induction of irritant contact dermatitis. Previously, we reported that mead acid (5,8,11-eicosatrienoic acid), an oleic acid metabolite, ameliorated skin inflammation in dinitrofluorobenzene-induced allergic contact hypersensitivity by inhibiting neutrophil infiltration and leukotriene B4 production by neutrophils. Here, we showed that mead acid also suppresses retinol-induced irritant contact dermatitis. In a murine model, we revealed that mead acid inhibited keratinocyte abnormalities such as keratinocyte hyperproliferation. Consistently, mead acid inhibited p38 MAPK (mitogen-activated protein kinase) phosphorylation, which is an essential signaling pathway in the keratinocyte hyperplasia induced by retinol. These inhibitory effects of mead acid were associated with the prevention of both keratinocyte hyperproliferation and the gene expression of neutrophil chemoattractants, including Cxcl1 and Cxcl2, and they were mediated by a PPAR (peroxisome proliferator-activated receptor)-α pathway. Our findings identified the anti-inflammatory effects of mead acid, the use of which can be expected to minimize the risk of adverse side effects associated with topical retinoid application. |
| first_indexed | 2024-04-10T16:56:49Z |
| format | Article |
| id | doaj.art-d7afa3a0165a44cea3a15e458946c45b |
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| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-10T16:56:49Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-d7afa3a0165a44cea3a15e458946c45b2023-02-07T07:22:53ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-02-011010.3389/fmolb.2023.10979551097955Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alphaAzusa Saika0Prabha Tiwari1Prabha Tiwari2Takahiro Nagatake3Takahiro Nagatake4Eri Node5Koji Hosomi6Tetsuya Honda7Kenji Kabashima8Jun Kunisawa9Jun Kunisawa10Jun Kunisawa11Jun Kunisawa12Jun Kunisawa13Jun Kunisawa14Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, JapanLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, JapanLaboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, JapanLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, JapanLaboratory of Functional Anatomy, Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki, Kanagawa, JapanLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, JapanLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, JapanDepartment of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, JapanDepartment of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, JapanLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, JapanInternational Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Minato, Tokyo, JapanGraduate School of Medicine, Graduate School of Dentistry, Graduate School of Pharmaceutical Sciences, Graduate School of Science, Osaka University, Suita, Osaka, JapanDepartment of Microbiology and Immunology, Graduate School of Medicine, Kobe University, Kobe, Hyogo, JapanResearch Organization for Nano and Life Innovation, Waseda University, Shinjuku, Tokyo, Japan0Graduate School of Biomedical and Health Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima, JapanRetinol is widely used in topical skincare products to ameliorate skin aging and treat acne and wrinkles; however, retinol and its derivatives occasionally have adverse side effects, including the induction of irritant contact dermatitis. Previously, we reported that mead acid (5,8,11-eicosatrienoic acid), an oleic acid metabolite, ameliorated skin inflammation in dinitrofluorobenzene-induced allergic contact hypersensitivity by inhibiting neutrophil infiltration and leukotriene B4 production by neutrophils. Here, we showed that mead acid also suppresses retinol-induced irritant contact dermatitis. In a murine model, we revealed that mead acid inhibited keratinocyte abnormalities such as keratinocyte hyperproliferation. Consistently, mead acid inhibited p38 MAPK (mitogen-activated protein kinase) phosphorylation, which is an essential signaling pathway in the keratinocyte hyperplasia induced by retinol. These inhibitory effects of mead acid were associated with the prevention of both keratinocyte hyperproliferation and the gene expression of neutrophil chemoattractants, including Cxcl1 and Cxcl2, and they were mediated by a PPAR (peroxisome proliferator-activated receptor)-α pathway. Our findings identified the anti-inflammatory effects of mead acid, the use of which can be expected to minimize the risk of adverse side effects associated with topical retinoid application.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1097955/fullmead acidretinolirritant contact dermatitis (ICD)lipid metabolitekeratinocytehyperproliferation |
| spellingShingle | Azusa Saika Prabha Tiwari Prabha Tiwari Takahiro Nagatake Takahiro Nagatake Eri Node Koji Hosomi Tetsuya Honda Kenji Kabashima Jun Kunisawa Jun Kunisawa Jun Kunisawa Jun Kunisawa Jun Kunisawa Jun Kunisawa Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha Frontiers in Molecular Biosciences mead acid retinol irritant contact dermatitis (ICD) lipid metabolite keratinocyte hyperproliferation |
| title | Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha |
| title_full | Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha |
| title_fullStr | Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha |
| title_full_unstemmed | Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha |
| title_short | Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha |
| title_sort | mead acid inhibits retinol induced irritant contact dermatitis via peroxisome proliferator activated receptor alpha |
| topic | mead acid retinol irritant contact dermatitis (ICD) lipid metabolite keratinocyte hyperproliferation |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1097955/full |
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