Development of an Ionic Liquid-Based Ultrasonic/Microwave-Assisted Simultaneous Distillation and Extraction Method for Separation of Camptothecin, 10-Hydroxycamptothecin, Vincoside-Lactam, and Essential Oils from the Fruits of Camptotheca acuminata Decne
An ionic liquid-based ultrasonic/microwave-assisted simultaneous distillation and extraction (IL-UMASDE) method for isolating camptothecin (CPT), 10-hydroxycamptothecin (HCPT), vincoside-lactam (VCS-LT), and essential oils (EOs) from Camptotheca acuminata Decne fruits was developed. The important pa...
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MDPI AG
2016-10-01
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| author | Chunjian Zhao Yukun Zhang Chunying Li Xin He Lei Yang Yujie Fu Jingjing Zhang Wenyan Zhao Yuangang Zu |
| author_facet | Chunjian Zhao Yukun Zhang Chunying Li Xin He Lei Yang Yujie Fu Jingjing Zhang Wenyan Zhao Yuangang Zu |
| author_sort | Chunjian Zhao |
| collection | DOAJ |
| description | An ionic liquid-based ultrasonic/microwave-assisted simultaneous distillation and extraction (IL-UMASDE) method for isolating camptothecin (CPT), 10-hydroxycamptothecin (HCPT), vincoside-lactam (VCS-LT), and essential oils (EOs) from Camptotheca acuminata Decne fruits was developed. The important parameters were optimized using single-factor and central composite design experiments. The optimum conditions were 0.75 M 1-octyl-3-methylimidazolium ([C8mim]Br) as the extraction solvent, a liquid–solid ratio of 13.7 mL/g, an extraction time of 33.2 min, a microwave power of 582 W, and a fixed ultrasonic power of 50 W. The yields of CPT, HCPT, and VCS-LT obtained under the optimum conditions were 2.463, 0.164, and 0.297 mg/g, respectively; these are 1.08-, 1.12-, and 1.04-fold higher, respectively, than those obtained by conventional 55% ethanol heat reflux extraction (HRE). The extraction time for the equilibrium yields of CPT, HCPT and VCS-LT using IL-UMASDE was 33.6%, 58.5%, 63.1%, and 66.8%, respectively, less than the corresponding times using IL-MASDE, IL-ultrasonic-assisted extraction (IL-UAE), 55% ethanol UAE and 55% ethanol HRE. The yield of EOs obtained using IL-UMASDE was 0.793 mg/g, i.e., 1.31-fold higher than that obtained by conventional hydrodistillation extraction (HDE). The components of the EOs obtained using IL-UMASDE and HDE were similar. The extraction time for the equilibrium yields of EOs using IL-UMASDE is 33.6%, 58.5%, 52.6%, and 72.3% lower than those for IL-MASDE, water-UMASDE, water-MASDE, and HDE, respectively. Compared with other extraction methods, IL-UMASDE gave the highest yields of CPT, HCPT, VCS-LT, and EOs and also had the shortest extraction time. IL-UMASDE is a potential green and highly efficient technique for the extraction of CPT, HCPT, VCS-LT, and EOs from Camptotheca acuminata Decne fruits. |
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| spelling | doaj.art-d7b0101abe7c4efbbb09b84ef97b9ebe2022-12-21T19:31:38ZengMDPI AGApplied Sciences2076-34172016-10-0161029310.3390/app6100293app6100293Development of an Ionic Liquid-Based Ultrasonic/Microwave-Assisted Simultaneous Distillation and Extraction Method for Separation of Camptothecin, 10-Hydroxycamptothecin, Vincoside-Lactam, and Essential Oils from the Fruits of Camptotheca acuminata DecneChunjian Zhao0Yukun Zhang1Chunying Li2Xin He3Lei Yang4Yujie Fu5Jingjing Zhang6Wenyan Zhao7Yuangang Zu8Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, ChinaAn ionic liquid-based ultrasonic/microwave-assisted simultaneous distillation and extraction (IL-UMASDE) method for isolating camptothecin (CPT), 10-hydroxycamptothecin (HCPT), vincoside-lactam (VCS-LT), and essential oils (EOs) from Camptotheca acuminata Decne fruits was developed. The important parameters were optimized using single-factor and central composite design experiments. The optimum conditions were 0.75 M 1-octyl-3-methylimidazolium ([C8mim]Br) as the extraction solvent, a liquid–solid ratio of 13.7 mL/g, an extraction time of 33.2 min, a microwave power of 582 W, and a fixed ultrasonic power of 50 W. The yields of CPT, HCPT, and VCS-LT obtained under the optimum conditions were 2.463, 0.164, and 0.297 mg/g, respectively; these are 1.08-, 1.12-, and 1.04-fold higher, respectively, than those obtained by conventional 55% ethanol heat reflux extraction (HRE). The extraction time for the equilibrium yields of CPT, HCPT and VCS-LT using IL-UMASDE was 33.6%, 58.5%, 63.1%, and 66.8%, respectively, less than the corresponding times using IL-MASDE, IL-ultrasonic-assisted extraction (IL-UAE), 55% ethanol UAE and 55% ethanol HRE. The yield of EOs obtained using IL-UMASDE was 0.793 mg/g, i.e., 1.31-fold higher than that obtained by conventional hydrodistillation extraction (HDE). The components of the EOs obtained using IL-UMASDE and HDE were similar. The extraction time for the equilibrium yields of EOs using IL-UMASDE is 33.6%, 58.5%, 52.6%, and 72.3% lower than those for IL-MASDE, water-UMASDE, water-MASDE, and HDE, respectively. Compared with other extraction methods, IL-UMASDE gave the highest yields of CPT, HCPT, VCS-LT, and EOs and also had the shortest extraction time. IL-UMASDE is a potential green and highly efficient technique for the extraction of CPT, HCPT, VCS-LT, and EOs from Camptotheca acuminata Decne fruits.http://www.mdpi.com/2076-3417/6/10/293ultrasonic/microwave-assisted simultaneous distillation and extractionionic liquidessential oilcamptothecinCamptotheca acuminata |
| spellingShingle | Chunjian Zhao Yukun Zhang Chunying Li Xin He Lei Yang Yujie Fu Jingjing Zhang Wenyan Zhao Yuangang Zu Development of an Ionic Liquid-Based Ultrasonic/Microwave-Assisted Simultaneous Distillation and Extraction Method for Separation of Camptothecin, 10-Hydroxycamptothecin, Vincoside-Lactam, and Essential Oils from the Fruits of Camptotheca acuminata Decne Applied Sciences ultrasonic/microwave-assisted simultaneous distillation and extraction ionic liquid essential oil camptothecin Camptotheca acuminata |
| title | Development of an Ionic Liquid-Based Ultrasonic/Microwave-Assisted Simultaneous Distillation and Extraction Method for Separation of Camptothecin, 10-Hydroxycamptothecin, Vincoside-Lactam, and Essential Oils from the Fruits of Camptotheca acuminata Decne |
| title_full | Development of an Ionic Liquid-Based Ultrasonic/Microwave-Assisted Simultaneous Distillation and Extraction Method for Separation of Camptothecin, 10-Hydroxycamptothecin, Vincoside-Lactam, and Essential Oils from the Fruits of Camptotheca acuminata Decne |
| title_fullStr | Development of an Ionic Liquid-Based Ultrasonic/Microwave-Assisted Simultaneous Distillation and Extraction Method for Separation of Camptothecin, 10-Hydroxycamptothecin, Vincoside-Lactam, and Essential Oils from the Fruits of Camptotheca acuminata Decne |
| title_full_unstemmed | Development of an Ionic Liquid-Based Ultrasonic/Microwave-Assisted Simultaneous Distillation and Extraction Method for Separation of Camptothecin, 10-Hydroxycamptothecin, Vincoside-Lactam, and Essential Oils from the Fruits of Camptotheca acuminata Decne |
| title_short | Development of an Ionic Liquid-Based Ultrasonic/Microwave-Assisted Simultaneous Distillation and Extraction Method for Separation of Camptothecin, 10-Hydroxycamptothecin, Vincoside-Lactam, and Essential Oils from the Fruits of Camptotheca acuminata Decne |
| title_sort | development of an ionic liquid based ultrasonic microwave assisted simultaneous distillation and extraction method for separation of camptothecin 10 hydroxycamptothecin vincoside lactam and essential oils from the fruits of camptotheca acuminata decne |
| topic | ultrasonic/microwave-assisted simultaneous distillation and extraction ionic liquid essential oil camptothecin Camptotheca acuminata |
| url | http://www.mdpi.com/2076-3417/6/10/293 |
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