Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis
BackgroundPeople living with HIV (PLWH) are at an increased risk of syphilis infection. The objectives of this study were to assess the overall prevalence of syphilis among PLWH in China and identify factors associated with syphilis infection among PLWH.MethodsWe searched Medline, Embase, China Nati...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1002342/full |
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| author | Yuelin Wu Wenqian Zhu Wenqian Zhu Chengqing Sun Xiaoli Yue Xiaoli Yue Min Zheng Gengfeng Fu Xiangdong Gong Xiangdong Gong |
| author_facet | Yuelin Wu Wenqian Zhu Wenqian Zhu Chengqing Sun Xiaoli Yue Xiaoli Yue Min Zheng Gengfeng Fu Xiangdong Gong Xiangdong Gong |
| author_sort | Yuelin Wu |
| collection | DOAJ |
| description | BackgroundPeople living with HIV (PLWH) are at an increased risk of syphilis infection. The objectives of this study were to assess the overall prevalence of syphilis among PLWH in China and identify factors associated with syphilis infection among PLWH.MethodsWe searched Medline, Embase, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), Wan-fang Data, and Chinese Biomedical Literature Database (CBM) to identify studies that reported the prevalence of syphilis among PLWH in China and were published in English or Chinese from January 1, 1990, to May 31, 2022. The reference lists of retrieved articles and relevant reviews were also checked to identify additional studies. A random-effect model was fitted to calculate the pooled syphilis prevalence among PLWH. Subgroup analyses, meta-regression analyses and sensitivity analyses were conducted to determine the potential source of heterogeneity.ResultsOf the 1,599 articles screened, 29 studies involving 34,740 participants were eligible for inclusion in this meta-analysis. The overall prevalence of syphilis among PLWH in China was 19.9% [95% confidence interval (CI): 15.4–24.8%, I2 = 98.9%]. Subgroup analysis showed that the pooled prevalence of syphilis among men who have sex with men (MSM) with HIV (21.9%, 95% CI: 17.2–26.9%) was much higher than that among heterosexuals (10.3%, 95% CI: 5.2–16.8%); there was regional diversity in the prevalence of syphilis, the highest in northern China (31.7%, 95% CI: 17.9–47.4%), followed by central-southern China (26.7%, 95% CI: 11.4–45.7%), and the lowest in northwestern China (15.0%, 95% CI: 6.9–25.4%); the syphilis prevalence among PLWH decreased as CD4 + T cell count increased (19.6% in CD4 + T cell < 200 vs. 8.7% in ≥ 500) and was higher among non-antiretroviral therapy (non-ART) HIV-infected patients (21.0%, 95% CI: 9.9–35.0%) than that among ART ones (16.1%, 95% CI: 3.9–34.3%).ConclusionsOur study showed a significantly high prevalence of syphilis among PLWH in China, particularly among MSM with HIV. Developing national guidelines for the integrated screening, monitoring, and management of HIV and syphilis as well as syphilis diagnosis and treatment training programs for physicians at designated HIV treatment hospitals is urgent and crucial to combat HIV and syphilis coinfection in China. |
| first_indexed | 2024-04-11T19:54:10Z |
| format | Article |
| id | doaj.art-d7b0272c6ab04e108919af7d12db81ca |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T19:54:10Z |
| publishDate | 2022-10-01 |
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| spelling | doaj.art-d7b0272c6ab04e108919af7d12db81ca2022-12-22T04:06:13ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.10023421002342Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysisYuelin Wu0Wenqian Zhu1Wenqian Zhu2Chengqing Sun3Xiaoli Yue4Xiaoli Yue5Min Zheng6Gengfeng Fu7Xiangdong Gong8Xiangdong Gong9Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, ChinaSchool of Public Health, Nanjing Medical University, Nanjing, ChinaSchool of Public Health, Nanjing Medical University, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, ChinaDepartment of STD Epidemiology, National Center for STD Control, Nanjing, ChinaDepartment of HIV/STD Control and Prevention, Guizhou Provincial Center for Disease Control and Prevention, Guiyang, ChinaDepartment of HIV/STD Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, ChinaDepartment of STD Epidemiology, National Center for STD Control, Nanjing, ChinaBackgroundPeople living with HIV (PLWH) are at an increased risk of syphilis infection. The objectives of this study were to assess the overall prevalence of syphilis among PLWH in China and identify factors associated with syphilis infection among PLWH.MethodsWe searched Medline, Embase, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), Wan-fang Data, and Chinese Biomedical Literature Database (CBM) to identify studies that reported the prevalence of syphilis among PLWH in China and were published in English or Chinese from January 1, 1990, to May 31, 2022. The reference lists of retrieved articles and relevant reviews were also checked to identify additional studies. A random-effect model was fitted to calculate the pooled syphilis prevalence among PLWH. Subgroup analyses, meta-regression analyses and sensitivity analyses were conducted to determine the potential source of heterogeneity.ResultsOf the 1,599 articles screened, 29 studies involving 34,740 participants were eligible for inclusion in this meta-analysis. The overall prevalence of syphilis among PLWH in China was 19.9% [95% confidence interval (CI): 15.4–24.8%, I2 = 98.9%]. Subgroup analysis showed that the pooled prevalence of syphilis among men who have sex with men (MSM) with HIV (21.9%, 95% CI: 17.2–26.9%) was much higher than that among heterosexuals (10.3%, 95% CI: 5.2–16.8%); there was regional diversity in the prevalence of syphilis, the highest in northern China (31.7%, 95% CI: 17.9–47.4%), followed by central-southern China (26.7%, 95% CI: 11.4–45.7%), and the lowest in northwestern China (15.0%, 95% CI: 6.9–25.4%); the syphilis prevalence among PLWH decreased as CD4 + T cell count increased (19.6% in CD4 + T cell < 200 vs. 8.7% in ≥ 500) and was higher among non-antiretroviral therapy (non-ART) HIV-infected patients (21.0%, 95% CI: 9.9–35.0%) than that among ART ones (16.1%, 95% CI: 3.9–34.3%).ConclusionsOur study showed a significantly high prevalence of syphilis among PLWH in China, particularly among MSM with HIV. Developing national guidelines for the integrated screening, monitoring, and management of HIV and syphilis as well as syphilis diagnosis and treatment training programs for physicians at designated HIV treatment hospitals is urgent and crucial to combat HIV and syphilis coinfection in China.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1002342/fullHIVsyphilisprevalencecoinfectionmeta-analysis |
| spellingShingle | Yuelin Wu Wenqian Zhu Wenqian Zhu Chengqing Sun Xiaoli Yue Xiaoli Yue Min Zheng Gengfeng Fu Xiangdong Gong Xiangdong Gong Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis Frontiers in Public Health HIV syphilis prevalence coinfection meta-analysis |
| title | Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis |
| title_full | Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis |
| title_fullStr | Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis |
| title_full_unstemmed | Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis |
| title_short | Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis |
| title_sort | prevalence of syphilis among people living with hiv and its implication for enhanced coinfection monitoring and management in china a meta analysis |
| topic | HIV syphilis prevalence coinfection meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1002342/full |
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