Not simply a matter of parents-Infants' sleep-wake patterns are associated with their regularity of eating.
In adults there are indications that regular eating patterns are related to better sleep quality. During early development, sleep and eating habits experience major maturational transitions. Further, the bacterial landscape of the gut microbiota undergoes a rapid increase in complexity. Yet little i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0291441&type=printable |
| _version_ | 1797315880989753344 |
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| author | Christophe Mühlematter Dennis S Nielsen Josue L Castro-Mejía Steven A Brown Björn Rasch Kenneth P Wright Jean-Claude Walser Sarah F Schoch Salome Kurth |
| author_facet | Christophe Mühlematter Dennis S Nielsen Josue L Castro-Mejía Steven A Brown Björn Rasch Kenneth P Wright Jean-Claude Walser Sarah F Schoch Salome Kurth |
| author_sort | Christophe Mühlematter |
| collection | DOAJ |
| description | In adults there are indications that regular eating patterns are related to better sleep quality. During early development, sleep and eating habits experience major maturational transitions. Further, the bacterial landscape of the gut microbiota undergoes a rapid increase in complexity. Yet little is known about the association between sleep, eating patterns and the gut microbiota. We first hypothesized that higher eating regularity is associated with more mature sleep patterns, and second, that this association is mediated by the maturational status of the gut microbiota. To test this hypothesis, we performed a longitudinal study in 162 infants to assess actigraphy, diaries of sleep and eating times, and stool microbiota composition at ages 3, 6 and 12 months. To comprehensively capture infants' habitual sleep-wake patterns, 5 sleep composites that characterize infants' sleep habits across multiple days in their home environment were computed. To assess timing of eating habits, we developed an Eating Regularity Index (ERI). Gut microbial composition was assessed by 16S rRNA gene amplicon sequencing, and its maturation was assessed based on alpha diversity, bacterial maturation index, and enterotype. First, our results demonstrate that increased eating regularity (higher ERI) in infants is associated with less time spent awake during the night (sleep fragmentation) and more regular sleep patterns. Second, the associations of ERI with sleep evolve with age. Third, the link between infant sleep and ERI remains significant when controlling for parents' subjectively rated importance of structuring their infant's eating and sleeping times. Finally, the gut microbial maturational markers did not account for the link between infant's sleep patterns and ERI. Thus, infants who eat more regularly have more mature sleep patterns, which is independent of the maturational status of their gut microbiota. Interventions targeting infant eating rhythm thus constitute a simple, ready-to-use anchor to improve sleep quality. |
| first_indexed | 2024-03-08T03:10:16Z |
| format | Article |
| id | doaj.art-d7b1198e4fa14f6dae868933ff9a6378 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-08T03:10:16Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d7b1198e4fa14f6dae868933ff9a63782024-02-13T05:34:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011810e029144110.1371/journal.pone.0291441Not simply a matter of parents-Infants' sleep-wake patterns are associated with their regularity of eating.Christophe MühlematterDennis S NielsenJosue L Castro-MejíaSteven A BrownBjörn RaschKenneth P WrightJean-Claude WalserSarah F SchochSalome KurthIn adults there are indications that regular eating patterns are related to better sleep quality. During early development, sleep and eating habits experience major maturational transitions. Further, the bacterial landscape of the gut microbiota undergoes a rapid increase in complexity. Yet little is known about the association between sleep, eating patterns and the gut microbiota. We first hypothesized that higher eating regularity is associated with more mature sleep patterns, and second, that this association is mediated by the maturational status of the gut microbiota. To test this hypothesis, we performed a longitudinal study in 162 infants to assess actigraphy, diaries of sleep and eating times, and stool microbiota composition at ages 3, 6 and 12 months. To comprehensively capture infants' habitual sleep-wake patterns, 5 sleep composites that characterize infants' sleep habits across multiple days in their home environment were computed. To assess timing of eating habits, we developed an Eating Regularity Index (ERI). Gut microbial composition was assessed by 16S rRNA gene amplicon sequencing, and its maturation was assessed based on alpha diversity, bacterial maturation index, and enterotype. First, our results demonstrate that increased eating regularity (higher ERI) in infants is associated with less time spent awake during the night (sleep fragmentation) and more regular sleep patterns. Second, the associations of ERI with sleep evolve with age. Third, the link between infant sleep and ERI remains significant when controlling for parents' subjectively rated importance of structuring their infant's eating and sleeping times. Finally, the gut microbial maturational markers did not account for the link between infant's sleep patterns and ERI. Thus, infants who eat more regularly have more mature sleep patterns, which is independent of the maturational status of their gut microbiota. Interventions targeting infant eating rhythm thus constitute a simple, ready-to-use anchor to improve sleep quality.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0291441&type=printable |
| spellingShingle | Christophe Mühlematter Dennis S Nielsen Josue L Castro-Mejía Steven A Brown Björn Rasch Kenneth P Wright Jean-Claude Walser Sarah F Schoch Salome Kurth Not simply a matter of parents-Infants' sleep-wake patterns are associated with their regularity of eating. PLoS ONE |
| title | Not simply a matter of parents-Infants' sleep-wake patterns are associated with their regularity of eating. |
| title_full | Not simply a matter of parents-Infants' sleep-wake patterns are associated with their regularity of eating. |
| title_fullStr | Not simply a matter of parents-Infants' sleep-wake patterns are associated with their regularity of eating. |
| title_full_unstemmed | Not simply a matter of parents-Infants' sleep-wake patterns are associated with their regularity of eating. |
| title_short | Not simply a matter of parents-Infants' sleep-wake patterns are associated with their regularity of eating. |
| title_sort | not simply a matter of parents infants sleep wake patterns are associated with their regularity of eating |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0291441&type=printable |
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