Role of Vacha (<em>Acorus calamus</em> Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study
Vacha (<i>Acorus calamus</i> Linn. (Acoraceae)) is a traditional Indian medicinal herb, which is practiced to treat a wide range of health ailments, including neurological, gastrointestinal, respiratory, metabolic, kidney, and liver disorders. The purpose of this paper is to provide a co...
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MDPI AG
2020-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/4/1176 |
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| author | Vineet Sharma Rohit Sharma DevNath Singh Gautam Kamil Kuca Eugenie Nepovimova Natália Martins |
| author_facet | Vineet Sharma Rohit Sharma DevNath Singh Gautam Kamil Kuca Eugenie Nepovimova Natália Martins |
| author_sort | Vineet Sharma |
| collection | DOAJ |
| description | Vacha (<i>Acorus calamus</i> Linn. (Acoraceae)) is a traditional Indian medicinal herb, which is practiced to treat a wide range of health ailments, including neurological, gastrointestinal, respiratory, metabolic, kidney, and liver disorders. The purpose of this paper is to provide a comprehensive up-to-date report on its ethnomedicinal use, phytochemistry, and pharmacotherapeutic potential, while identifying potential areas for further research. To date, 145 constituents have been isolated from this herb and identified, including phenylpropanoids, sesquiterpenoids, and monoterpenes. Compelling evidence is suggestive of the biopotential of its various extracts and active constituents in several metabolic and neurological disorders, such as anticonvulsant, antidepressant, antihypertensive, anti-inflammatory, immunomodulatory, neuroprotective, cardioprotective, and anti-obesity effects. The present extensive literature survey is expected to provide insights into the involvement of several signaling pathways and oxidative mechanisms that can mitigate oxidative stress, and other indirect mechanisms modulated by active biomolecules of <i>A. calamus</i> to improve neurological and metabolic disorders. |
| first_indexed | 2024-03-10T20:22:40Z |
| format | Article |
| id | doaj.art-d7b151fbb3a64d659c00980067b93e48 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T20:22:40Z |
| publishDate | 2020-04-01 |
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| spelling | doaj.art-d7b151fbb3a64d659c00980067b93e482023-11-19T22:07:30ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-0194117610.3390/jcm9041176Role of Vacha (<em>Acorus calamus</em> Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical StudyVineet Sharma0Rohit Sharma1DevNath Singh Gautam2Kamil Kuca3Eugenie Nepovimova4Natália Martins5Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh 221005, IndiaDepartment of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh 221005, IndiaDepartment of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh 221005, IndiaDepartment of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanskeho 62, 50003 Hradec Králové, Czech RepublicDepartment of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanskeho 62, 50003 Hradec Králové, Czech RepublicFaculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, PortugalVacha (<i>Acorus calamus</i> Linn. (Acoraceae)) is a traditional Indian medicinal herb, which is practiced to treat a wide range of health ailments, including neurological, gastrointestinal, respiratory, metabolic, kidney, and liver disorders. The purpose of this paper is to provide a comprehensive up-to-date report on its ethnomedicinal use, phytochemistry, and pharmacotherapeutic potential, while identifying potential areas for further research. To date, 145 constituents have been isolated from this herb and identified, including phenylpropanoids, sesquiterpenoids, and monoterpenes. Compelling evidence is suggestive of the biopotential of its various extracts and active constituents in several metabolic and neurological disorders, such as anticonvulsant, antidepressant, antihypertensive, anti-inflammatory, immunomodulatory, neuroprotective, cardioprotective, and anti-obesity effects. The present extensive literature survey is expected to provide insights into the involvement of several signaling pathways and oxidative mechanisms that can mitigate oxidative stress, and other indirect mechanisms modulated by active biomolecules of <i>A. calamus</i> to improve neurological and metabolic disorders.https://www.mdpi.com/2077-0383/9/4/1176<i>Acorus calamus</i>ethnomedicinalphytochemistrytoxicitypharmacological actionclinical trial |
| spellingShingle | Vineet Sharma Rohit Sharma DevNath Singh Gautam Kamil Kuca Eugenie Nepovimova Natália Martins Role of Vacha (<em>Acorus calamus</em> Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study Journal of Clinical Medicine <i>Acorus calamus</i> ethnomedicinal phytochemistry toxicity pharmacological action clinical trial |
| title | Role of Vacha (<em>Acorus calamus</em> Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study |
| title_full | Role of Vacha (<em>Acorus calamus</em> Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study |
| title_fullStr | Role of Vacha (<em>Acorus calamus</em> Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study |
| title_full_unstemmed | Role of Vacha (<em>Acorus calamus</em> Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study |
| title_short | Role of Vacha (<em>Acorus calamus</em> Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study |
| title_sort | role of vacha em acorus calamus em linn in neurological and metabolic disorders evidence from ethnopharmacology phytochemistry pharmacology and clinical study |
| topic | <i>Acorus calamus</i> ethnomedicinal phytochemistry toxicity pharmacological action clinical trial |
| url | https://www.mdpi.com/2077-0383/9/4/1176 |
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