In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details

In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details

Acquired long QT syndrome, mostly as a result of drug block of the Kv11. 1 potassium channel in the heart, is characterized by delayed cardiac myocyte repolarization, prolongation of the T interval on the ECG, syncope and sudden cardiac death due to the polymorphic ventricular arrhythmia Torsade de...

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Bibliographic Details
Main Authors:	William Lee, Monique J. Windley, Jamie I. Vandenberg, Adam P. Hill
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-11-01
Series:	Frontiers in Physiology
Subjects:	kv11.1 herg acquired long QT syndrome arrhythmia pharmacology CiPA
Online Access:	http://journal.frontiersin.org/article/10.3389/fphys.2017.00934/full

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