Reducing farnesyl diphosphate synthase levels activates Vγ9Vδ2 T cells and improves tumor suppression in murine xenograft cancer models

Reducing farnesyl diphosphate synthase levels activates Vγ9Vδ2 T cells and improves tumor suppression in murine xenograft cancer models

Human Vγ9Vδ2 T cells are attractive candidates for cancer immunotherapy due to their potent capacity for tumor recognition and cytolysis of many tumor cell types. However, efforts to deploy clinical strategies for Vγ9Vδ2 T cell cancer therapy are hampered by insufficient potency. We are pursuing an...

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Bibliographic Details
Main Authors: Mei-Ling Liou, Tyler Lahusen, Haishan Li, Lingzhi Xiao, C. David Pauza
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
T-cell
gamma delta T-cell
cancer
tumor
immunotherapy
shRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012051/full

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