Bioengineered embryoids mimic post-implantation development in vitro

Previous approaches to derive embryoids either lack physiological morphology and signaling interactions, or are unconducive to model post-gastrulation development. Here the authors use a high-throughput approach to induce mouse embryonic stem cells into epiblast-like aggregates, which are then co-cu...

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Bibliographic Details
Main Authors: Mehmet U. Girgin, Nicolas Broguiere, Sylke Hoehnel, Nathalie Brandenberg, Bastien Mercier, Alfonso Martinez Arias, Matthias P. Lutolf
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25237-8