Effects of royal jelly supplementation on regulatory T cells in children with SLE
Background and objective: To our knowledge, no previous studies have focused on the immunomodulatory effects of fresh royal jelly (RJ) administration on systemic lupus erythematosus (SLE) in humans. Our aim was to study the effect of fresh RJ administration on the disease course in children with SLE...
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| Format: | Article |
| Language: | English |
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Swedish Nutrition Foundation
2016-11-01
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| Series: | Food & Nutrition Research |
| Subjects: | |
| Online Access: | http://www.foodandnutritionresearch.net/index.php/fnr/article/view/32963/50024 |
| _version_ | 1811300594115149824 |
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| author | Asmaa M. Zahran Khalid I. Elsayh Khaled Saad Esraa M.A. Eloseily Naglaa S. Osman Mohamd A. Alblihed Gamal Badr Mohamed H. Mahmoud |
| author_facet | Asmaa M. Zahran Khalid I. Elsayh Khaled Saad Esraa M.A. Eloseily Naglaa S. Osman Mohamd A. Alblihed Gamal Badr Mohamed H. Mahmoud |
| author_sort | Asmaa M. Zahran |
| collection | DOAJ |
| description | Background and objective: To our knowledge, no previous studies have focused on the immunomodulatory effects of fresh royal jelly (RJ) administration on systemic lupus erythematosus (SLE) in humans. Our aim was to study the effect of fresh RJ administration on the disease course in children with SLE with some immunological markers (CD4+ and CD8+ regulatory T cells and T lymphocytes apoptosis). Methods: This was an open-label study in which 20 SLE children received 2 g of freshly prepared RJ daily, for 12 weeks. Results: The percentages of CD4+ CD25+high FOXP3+cells (CD4+ regulatory T cells) and CD8+CD25+high FOXP3+cells (CD8+ regulatory T cells) were significantly increased after RJ treatment when compared with baseline values. Apoptotic CD4 T lymphocytes were significantly decreased after RJ therapy when compared with baseline values and the control group. Conclusion: This is the first human study on the effect of RJ supplementation in children with SLE. Our results showed improvements with 3-month RJ treatment with regard to the clinical severity score and laboratory markers for the disease. At this stage, it is a single study with a small number of patients, and a great deal of additional wide-scale randomized controlled studies are needed to critically validate the efficacy of RJ in SLE. |
| first_indexed | 2024-04-13T06:53:31Z |
| format | Article |
| id | doaj.art-d7b8fef0fd64417d8f6cd2dea7dd9956 |
| institution | Directory Open Access Journal |
| issn | 1654-661X |
| language | English |
| last_indexed | 2024-04-13T06:53:31Z |
| publishDate | 2016-11-01 |
| publisher | Swedish Nutrition Foundation |
| record_format | Article |
| series | Food & Nutrition Research |
| spelling | doaj.art-d7b8fef0fd64417d8f6cd2dea7dd99562022-12-22T02:57:20ZengSwedish Nutrition FoundationFood & Nutrition Research1654-661X2016-11-0160011010.3402/fnr.v60.3296332963Effects of royal jelly supplementation on regulatory T cells in children with SLEAsmaa M. Zahran0Khalid I. Elsayh1Khaled Saad2Esraa M.A. Eloseily3Naglaa S. Osman4Mohamd A. Alblihed5Gamal Badr6Mohamed H. Mahmoud7 Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt Medical Biochemistry Department, College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia Zoology Department, Laboratory of Immunology & Molecular Physiology, Faculty of Science, Assiut University, Assiut, Egypt Deanship of Scientific Research, King Saud University, Riyadh, Kingdom of Saudi ArabiaBackground and objective: To our knowledge, no previous studies have focused on the immunomodulatory effects of fresh royal jelly (RJ) administration on systemic lupus erythematosus (SLE) in humans. Our aim was to study the effect of fresh RJ administration on the disease course in children with SLE with some immunological markers (CD4+ and CD8+ regulatory T cells and T lymphocytes apoptosis). Methods: This was an open-label study in which 20 SLE children received 2 g of freshly prepared RJ daily, for 12 weeks. Results: The percentages of CD4+ CD25+high FOXP3+cells (CD4+ regulatory T cells) and CD8+CD25+high FOXP3+cells (CD8+ regulatory T cells) were significantly increased after RJ treatment when compared with baseline values. Apoptotic CD4 T lymphocytes were significantly decreased after RJ therapy when compared with baseline values and the control group. Conclusion: This is the first human study on the effect of RJ supplementation in children with SLE. Our results showed improvements with 3-month RJ treatment with regard to the clinical severity score and laboratory markers for the disease. At this stage, it is a single study with a small number of patients, and a great deal of additional wide-scale randomized controlled studies are needed to critically validate the efficacy of RJ in SLE.http://www.foodandnutritionresearch.net/index.php/fnr/article/view/32963/50024royal jellyregulatory T cellschildrensystemic lupus erythematosus |
| spellingShingle | Asmaa M. Zahran Khalid I. Elsayh Khaled Saad Esraa M.A. Eloseily Naglaa S. Osman Mohamd A. Alblihed Gamal Badr Mohamed H. Mahmoud Effects of royal jelly supplementation on regulatory T cells in children with SLE Food & Nutrition Research royal jelly regulatory T cells children systemic lupus erythematosus |
| title | Effects of royal jelly supplementation on regulatory T cells in children with SLE |
| title_full | Effects of royal jelly supplementation on regulatory T cells in children with SLE |
| title_fullStr | Effects of royal jelly supplementation on regulatory T cells in children with SLE |
| title_full_unstemmed | Effects of royal jelly supplementation on regulatory T cells in children with SLE |
| title_short | Effects of royal jelly supplementation on regulatory T cells in children with SLE |
| title_sort | effects of royal jelly supplementation on regulatory t cells in children with sle |
| topic | royal jelly regulatory T cells children systemic lupus erythematosus |
| url | http://www.foodandnutritionresearch.net/index.php/fnr/article/view/32963/50024 |
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