Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis

Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis

BackgroundNotch signaling is critical for regulating the function of vascular endothelial cells (ECs). However, the effect of the intracellular domain of Notch1 (NICD) on EC injury in sepsis remains unclear.MethodsWe established a cell model of vascular endothelial dysfunction and induced sepsis in...

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Bibliographic Details
Main Authors: Tingyan Liu, Caiyan Zhang, Jiayun Ying, Yaodong Wang, Gangfeng Yan, Yufeng Zhou, Guoping Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
NICD
vascular endothelial dysfunction
melatonin
LPS (lipopolysaccharide)
sepsis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1134556/full

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