An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals

Serotonin (5-HT) plays many important roles in reward, punishment, patience and beyond, and optogenetic stimulation of 5-HT neurons has not crisply parsed them. The authors report a novel analysis of a reward-based decision-making experiment, and show that 5-HT stimulation increases the learning rat...

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Bibliographic Details
Main Authors: Kiyohito Iigaya, Madalena S. Fonseca, Masayoshi Murakami, Zachary F. Mainen, Peter Dayan
Format: Article
Language:English
Published: Nature Portfolio 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04840-2
Description
Summary:Serotonin (5-HT) plays many important roles in reward, punishment, patience and beyond, and optogenetic stimulation of 5-HT neurons has not crisply parsed them. The authors report a novel analysis of a reward-based decision-making experiment, and show that 5-HT stimulation increases the learning rate, but only on a select subset of choices.
ISSN:2041-1723