An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals

Serotonin (5-HT) plays many important roles in reward, punishment, patience and beyond, and optogenetic stimulation of 5-HT neurons has not crisply parsed them. The authors report a novel analysis of a reward-based decision-making experiment, and show that 5-HT stimulation increases the learning rat...

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Main Authors: Kiyohito Iigaya, Madalena S. Fonseca, Masayoshi Murakami, Zachary F. Mainen, Peter Dayan
Format: Article
Language:English
Published: Nature Portfolio 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04840-2
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author Kiyohito Iigaya
Madalena S. Fonseca
Masayoshi Murakami
Zachary F. Mainen
Peter Dayan
author_facet Kiyohito Iigaya
Madalena S. Fonseca
Masayoshi Murakami
Zachary F. Mainen
Peter Dayan
author_sort Kiyohito Iigaya
collection DOAJ
description Serotonin (5-HT) plays many important roles in reward, punishment, patience and beyond, and optogenetic stimulation of 5-HT neurons has not crisply parsed them. The authors report a novel analysis of a reward-based decision-making experiment, and show that 5-HT stimulation increases the learning rate, but only on a select subset of choices.
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spelling doaj.art-d7bc3de7103a474cb12f9bf2b53a8a922022-12-21T19:27:49ZengNature PortfolioNature Communications2041-17232018-06-019111010.1038/s41467-018-04840-2An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervalsKiyohito Iigaya0Madalena S. Fonseca1Masayoshi Murakami2Zachary F. Mainen3Peter Dayan4Gatsby Computational Neuroscience Unit, University College LondonChampalimaud Research, Champalimaud Centre for the UnknownChampalimaud Research, Champalimaud Centre for the UnknownChampalimaud Research, Champalimaud Centre for the UnknownGatsby Computational Neuroscience Unit, University College LondonSerotonin (5-HT) plays many important roles in reward, punishment, patience and beyond, and optogenetic stimulation of 5-HT neurons has not crisply parsed them. The authors report a novel analysis of a reward-based decision-making experiment, and show that 5-HT stimulation increases the learning rate, but only on a select subset of choices.https://doi.org/10.1038/s41467-018-04840-2
spellingShingle Kiyohito Iigaya
Madalena S. Fonseca
Masayoshi Murakami
Zachary F. Mainen
Peter Dayan
An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
Nature Communications
title An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
title_full An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
title_fullStr An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
title_full_unstemmed An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
title_short An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
title_sort effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
url https://doi.org/10.1038/s41467-018-04840-2
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